{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:58:01Z","timestamp":1791356281506,"version":"4.3.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5734,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients who are homozygous for ataxia\u2010telangiectasia (AT) have an exceptionally high incidence of cancer. Heterozygous individuals for the disease have been reported to be at an increased risk of cancer, particularly breast cancer in female carriers. We have analyzed eight Norwegian families with AT for cancer incidence in the parents, in the parents' sibs, grandparents, and grandparents' sibs. Two of the obligate heterozygote females have had premenopausal breast cancer. This incidence is significantly higher than expected for that group. No increase in the cancer incidence was observed in the parents' sibs, the grandparents, or the grandparents' sibs. Since the incidence of AT is low, data from many sources have to be combined to allow any conclusion.<\/jats:p>","DOI":"10.1002\/gcc.2870020412","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:52:18Z","timestamp":1172098338000},"page":"339-340","source":"Crossref","is-referenced-by-count":98,"title":["Breast cancer and other cancers in Norwegian families with ataxia\u2010telangiectasia"],"prefix":"10.1002","volume":"2","author":[{"given":"Anne\u2010Lise","family":"B\u00f8rresen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tone Ikdahl","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steinar","family":"Tretli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"Heiberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"Ataxia\u2010Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood","author":"Boder E","year":"1985"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001113220201"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/336577a0"},{"key":"e_1_2_1_5_1","first-page":"67","volume-title":"Ataxia\u2010Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood","author":"Hanawalt P","year":"1985"},{"key":"e_1_2_1_6_1","first-page":"6162","article-title":"Fourth International Workshop on Ataxia\u2010Telangiectasia. Meeting Report","volume":"49","author":"Lehman AR","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","first-page":"89","article-title":"Mortality and cancer incidence in 263 patients with ataxia\u2010telangiectasia","volume":"77","author":"Morrell D","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_8_1","first-page":"89","volume-title":"Ataxia\u2010Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood","author":"Painter RB","year":"1985"},{"key":"e_1_2_1_9_1","first-page":"2929","article-title":"Cancer in homozygotes and heterozygotes of ataxia\u2010telangiectasia and Xeroderma Pigmentosum in Britain","volume":"48","author":"Pippard EE","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705213162101"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90004-T"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90002-R"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870020412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870020412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:28:55Z","timestamp":1695720535000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870020412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1002\/gcc.2870020412"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870020412","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}