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In two cases, partial trisomy for chromosome 2 resulted from direct duplication of long arm material with the shortest region of overlap being 2q23\u20102q35. In one tumor, each metaphase also contained a variable number of double minute chromosomes found not to derive from <jats:italic>NMYC<\/jats:italic> amplification. Interestingly, trisomy for 2q and trisomy 20 are also characteristic events in pediatric embryonal rhabdomyosarcomas. Furthermore, others have reported loss of heterozygosity for the short arm of chromosome 11 in both hepatoblastoma and childhood embryonal rhabdomyosarcoma, and both these malignant diseases are associated with Beckwith\u2010Wiedemann syndrome. These cytogenetic and molecular findings suggest a parallel pathway of genetic steps in the initiation and\/or progression of tumors of embryonal liver and skeletal muscle.<\/jats:p>","DOI":"10.1002\/gcc.2870030107","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:52:17Z","timestamp":1172098337000},"page":"37-43","source":"Crossref","is-referenced-by-count":56,"title":["Consistent cytogenetic aberrations in hepatoblastoma: A common pathway of genetic alterations in embryonal liver and skeletal muscle malignancies?"],"prefix":"10.1002","volume":"3","author":[{"given":"Jonathan A.","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry 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