{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:20:48Z","timestamp":1698124848431},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5614,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously shown that the reciprocal translocation t(6;7) associated with the spontaneous immunocytoma of the Louvain rat (RIC) leads to the juxtaposition of <jats:italic>myc<\/jats:italic> to the <jats:italic>lgH<\/jats:italic> cluster. In 10 of 14 tumors investigated the breakpoints on the <jats:italic>myc<\/jats:italic> carrying chromosome were clustered in a 1.5 kb region 5\u2032 of the intact gene, proximal to the <jats:italic>myc<\/jats:italic> promoters. In this paper we describe the effect of the translocation on <jats:italic>myc<\/jats:italic> transcription in the RIC system. Run\u2010on analysis showed transcriptional attenuation in the normal rat <jats:italic>myc<\/jats:italic> gene, similar to the situation in mice and humans. The attenuation was almost completely abrogated in the three immunocytomas studied. Sequence analysis of two tumors failed to reveal any structural changes within exon I, as found by others in Burkitt's lymphoma. We also show that the transcriptional initiation of <jats:italic>myc<\/jats:italic> mRNA is changed in the RICs. In an established line of rat fibroblasts (Rat\u20102), the more distal <jats:italic>myc<\/jats:italic> promoter (P2) is the preferred site of initiation. In RIC, however, only 30% of transcripts were initiated from P2. We found that 40% of the transcripts were initiated from PI and 30% from a novel promoter, designated PI a, located between PI and P2.<\/jats:p>","DOI":"10.1002\/gcc.2870030210","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:50:22Z","timestamp":1172098222000},"page":"142-148","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptional deregulation of <i>myc<\/i> in<i>lgH\/myc<\/i> 6;7 translocation carrying rat immunocytomas"],"prefix":"10.1002","volume":"3","author":[{"given":"H\u00e5kan","family":"Axelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren S.","family":"Pear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinmay 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