{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:24:51Z","timestamp":1700220291852},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5430,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deletions of the short arm of chromosome 3 and associated allele losses have been reported in the majority of sporadic renal cell carcinomas (RCC). On the basis of the combined cytogenetic and molecular data, it is reasonable to assume that a putative RCC locus, which contributes to tumor development by its loss, is located telomerically of the D3F15S2 site. Using H3E4, a D3F1SS2\u2010specific probe, we have isolated a cDNA clone (c1.4\u20132), and a sequence comparison revealed that the cDNA clone corresponds to the human acyl\u2010peptide hydrolase gene. The gene is fairly universally expressed, but in RCC biopsies its expression is severely reduced, compared to the normal kidney. Cl.4\u20132 was used for in situ hybridization on metaphase chromosomes prepared from an Epstein\u2010Barr virus (EBV) transformed lymphoblastoid cell line, derived from a t(3;8) (p14.2;q24.1) carrying member of the RCC family described by Cohen et al. in 1979 (N Engl J Med: 301:592\u2013595). Carriers of this translocation regularly develop RCC by middle age. We now report that D3F15S2 is localized on the telomeric side of the constitutional breakpoint, in 3p21. The region of 3p affected by this familial translocation is thus not identical with the region of 3p most frequently deleted in sporadic RCC.<\/jats:p>","DOI":"10.1002\/gcc.2870030513","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:50:12Z","timestamp":1172098212000},"page":"403-406","source":"Crossref","is-referenced-by-count":10,"title":["Involvement of 3p Deletions in Sporadic and Hereditary Forms of Renal Cell Carcinoma"],"prefix":"10.1002","volume":"3","author":[{"given":"Ferenc","family":"Boldog","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Arheden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Imreh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil","family":"Strombeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Szekely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikard","family":"Erlandsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Marcsek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Sumegi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mitelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132513"},{"key":"e_1_2_1_3_1","first-page":"1390","article-title":"Chromosomal deletions in renal cell carcinoma","volume":"49","author":"Bergerheim U","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"BodmerWF(1989)Hereditary colorectal cancer\u2014a commentary. Proc 4th Int Symp Colorectal Cancer. Kobe Japan.","DOI":"10.1007\/978-4-431-68337-7_4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90098-8"},{"key":"e_1_2_1_6_1","first-page":"428","article-title":"Sequences homologous to the human D1S1 locus present on human chromosome 3","volume":"38","author":"Carritt B","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909133011107"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90145-8"},{"key":"e_1_2_1_9_1","first-page":"1207","article-title":"A gene near the DNF15S2 site on 3p is expressed in normal human kidney but not or only at a severely reduced level in 11 of 15 primary renal cell carcinomas (RCC)","volume":"5","author":"Erlandsson R","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_10_1","first-page":"1293","article-title":"The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase","volume":"6","author":"Erlandsson R","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90013-1"},{"key":"e_1_2_1_13_1","first-page":"23","article-title":"Expression in lung cancer of a transcribed sequence at the DNF15S2 locus at chromosome 3p21","volume":"10","author":"Harbour JW","year":"1990","journal-title":"Anticancer Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90195-G"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/330578a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.5.1571"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132783"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90342-X"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90028-1"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/327721a0"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870030513","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870030513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T22:15:29Z","timestamp":1698012929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870030513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1002\/gcc.2870030513"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870030513","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}