{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:18:29Z","timestamp":1785842309558,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5369,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six squamous cell carcinomas of the vulva (SCV) were karyotyped in short\u2010term culture and in early passages as established cell lines. Each tumor was cytogenetically distinct, contained multiple chromosome rearrangements, and was karyotypically stable in culture. Heterogeneity within individual tumors was manifested by the presence of more than one clonal population, but the clones within each tumor were closely related to one another. Seven consistent chromosome abnormalities found in five of the six tumors were: losses of 3p 14\u2010cen, 8pter\u2010p 11, 22q 13.1 \u2010q 13.2, and the short arm of the inactive X; chromosome gains involving 3q25\u2010qter and 11 q21; and rearrangement breakpoints at 5cen\u2010q 12. Ten additional chromosome changes were observed in four of the six SCVs, and together, 22 changes occurred in at least three of the tumors. Two specific losses, 10q23\u2010q25 and 18q22\u2010q23, were present in all four tumors that exhibited biologically aggressive behavior in vivo, but these losses were not found in the tumors of the two long\u2010term survivors. These findings indicate that: 1) SCVs are genetically complex, but homogeneous; 2) loss of 18q22\u2010q23 and loss of 10q23\u2010q25 may be associated with a poor prognosis; and 3) development and progression of SCV appear to result from cumulative effects of altered gene dosage at multiple, consistent loci.<\/jats:p>","DOI":"10.1002\/gcc.2870030604","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:44:25Z","timestamp":1172097865000},"page":"420-432","source":"Crossref","is-referenced-by-count":63,"title":["Consistent Chromosome Abnormalities in Squamous Cell Carcinoma of the Vulva"],"prefix":"10.1002","volume":"3","author":[{"given":"Maria J.","family":"Worsham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seija 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