{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:46:09Z","timestamp":1791179169818,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5369,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HSB\u20102 is a cell line derived from a patient who had T\u2010cell acute lymphoblastic leukemia (T\u2010cell ALL) with a t( 1;7)(p34;q34). We used a genomic probe from the T\u2010cell receptor beta (TCRB) locus (7q34) to identify DNA rearrangements in HSB\u20102. Two rearranged Bg\/11 DNA fragments were cloned, and one of these clones was shown to contain the translocation breakpoint on the derivative chromosome 1 [der(1)]. We used a probe derived from this clone to isolate an unrearranged phage clone encompassing the breakpoint at 1 p34. The restriction map of this clone was compared to the published maps of known protooncogenes located at 1 p32\u201334. By restriction mapping, Southern blot analysis, and DNA sequencing we showed that the translocation breakpoint on chromosome 1 is located within the first intron of the LCK gene. The LCK gene codes for p56<jats:sup>lck<\/jats:sup>, a member of the SRC family of cytoplasmic tyrosine protein kinases. There are two classes of LCK transcripts (type 1 and type 11), each expressed from a distinct promoter, and each having a unique 5\u2032 untranslated region (UTR); the protein coding regions of the two classes are identical. The breakpoint in the t( 1;7) separates the two LCK promoters and juxtaposes the constant region of the TCRB locus with the proximal promoter and with the protein\u2010coding region of the LCK gene on the der(1) chromosome.<\/jats:p>","DOI":"10.1002\/gcc.2870030608","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:44:25Z","timestamp":1172097865000},"page":"461-467","source":"Crossref","is-referenced-by-count":34,"title":["The LCK Gene Is Involved in the t(1;7)(p34;q34) in the T\u2010Cell Acute Lymphoblastic Leukemia Derived Cell Line, HSB\u20102"],"prefix":"10.1002","volume":"3","author":[{"given":"Robert C.","family":"Burnett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna M.","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel O.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1121","article-title":"Direct implantation and serial transplantation of lymphoblastic leukemia in hamsters","volume":"28","author":"Adams RA","year":"1968","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1128\/jvi.62.11.4113-4122.1988","article-title":"Transcriptional activation of lck by retrovirus promoter insertion between two lymphoid\u2010specific promoters","volume":"62","author":"Alder HT","year":"1988","journal-title":"J Virol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07535.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01560663"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08126.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.2.682"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2406902"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.10.5486"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113453"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/306239a0"},{"key":"e_1_2_1_13_1","first-page":"856","article-title":"Expression of the human T\u2010cell\u2010specific tyrosine kinase YT16(lck) message in leukemic T\u2010cell lines","volume":"48","author":"Koga Y","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90169-2"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7400"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02566.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/332171a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010310"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00405069"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240380206"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1182\/blood.V69.1.131.131","article-title":"7q23\u2013q36 translocations in childhood T cell leukemia: Cytogenetic evidence for involvement of the T cell receptor \u03b2\u2010chain gene","volume":"69","author":"Raimondi SC","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90667-2"},{"key":"e_1_2_1_23_1","first-page":"3816","article-title":"Molecular cytogenetics: Rosetta Stone for understanding cancer. 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