{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:23:11Z","timestamp":1770477791898,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5308,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The t(10;14)(q24;q11) is observed in the leukemia cells of 5\u201310% of cases of T\u2010cell acute lymphoblastic leukemia (T\u2010ALL). Recently, molecular analyses of a number of these translocations revealed simple reciprocal translocations between the T\u2010cell receptor delta chain gene (<jats:italic>TCRD<\/jats:italic>) and a region of 10q24. We have characterized, at the molecular level, a t(10;14)(q24;q11) in a patient with T\u2010ALL. The translocation in this case, in contrast to the previous cases, is part of a complex genetic rearrangement. In addition to a reciprocal translocation between the <jats:italic>D\u03b43<\/jats:italic> gene segment of <jats:italic>TCRD<\/jats:italic> and a region of 10q24, a local inversion occurred within <jats:italic>TCRD<\/jats:italic>, involving the <jats:italic>D\u03b42<\/jats:italic> and <jats:italic>V\u03b42<\/jats:italic> gene segments. As a consequence, the entire joining and constant regions and most of the diversity regions of <jats:italic>TCRD<\/jats:italic> are located on the derivative 14 chromosome, whereas the joining and constant regions of <jats:italic>TCRA<\/jats:italic> are positioned on the derivative 10 chromosome. The chromosome 10 breakpoint in our patient, as in other t(10;14), clusters within a 9 kb breakpoint region. The occurrence of seven breakpoints within a localized region of chromosome 10 implies the existence of a nearby gene whose activation may have conferred a selective advantage on the leukemia cells. Moreover, as in the previous cases, the translocation in the present study exhibits recombination signal sequences or signal\u2010like sequences adjacent to the breakpoint junction. The presence of such motifs suggests the involvement of the recombinase enzyme system in the generation of this genetic alteration.<\/jats:p>","DOI":"10.1002\/gcc.2870040105","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:13:41Z","timestamp":1172099621000},"page":"32-40","source":"Crossref","is-referenced-by-count":8,"title":["A complex genetic rearrangement in a t(10;14)(q24;q11) associated with T\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"4","author":[{"given":"James K.","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Le Beau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel O.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Shows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02825.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08402.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.5.1403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1182\/blood.V67.4.1181.1181","article-title":"A new translocation, t(10,14)(q24;q11), in T cell neoplasia","volume":"67","author":"Dub\u00e9 ID","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1182\/blood.V78.11.2996.2996","article-title":"A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translation t(10;14)","volume":"78","author":"Dub\u00e9 ID","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3486470"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1676542"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.7.1053"},{"key":"e_1_2_1_10_1","volume-title":"An International System for Human Cytogenetic Nomenclature (published in collaboration with Cytogenet Cell Genet)","author":"ISCN","year":"1985"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.13.4543"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.11.4161"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.8900"},{"key":"e_1_2_1_14_1","first-page":"135","volume-title":"Association of Cytogenetic Technologists","author":"Le Beau MM","year":"1984"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020309"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.2124"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2156339"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.6.1491"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.10.3439"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2824"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03432.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3161"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870040105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870040105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T14:24:57Z","timestamp":1698071097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870040105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/gcc.2870040105"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870040105","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}