{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:04Z","timestamp":1760188864368},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5308,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between karyotype and expression of the T\u2010cell receptor (TCR) proteins was examined in 19 patients with T\u2010lineage acute lymphoblastic leukemia (T\u2010ALL). All patients expressed CD3 molecules in the cytoplasm or on the cell membrane. Patients were classified according to TCR expression thus: no TCR expression (TCR\u2013), six cases; cytoplasmic expression of TCR beta chain (cTCRB) only, six cases; membrane expression of TCR alpha and beta chains (mTCRAB), five cases; membrane expression of TCR gamma and delta (mTCRGD), two cases. A chromosomally abnormal clone was detected in 15 cases. The most common site of chromosomal change was at 14q11 (seven cases), the chromosomal band to which <jats:italic>TCRA<\/jats:italic> and <jats:italic>TCRD<\/jats:italic> have been mapped; as a deletion (two cases); or as a translocation with reciprocal breakpoints in bands containing the <jats:italic>TCRG<\/jats:italic> (7p15); <jats:italic>TCRB<\/jats:italic> (7q35); or putative oncogenes <jats:italic>HOX11<\/jats:italic> (10q24), <jats:italic>RBTN2<\/jats:italic> (11p13), or <jats:italic>MYC<\/jats:italic> (8q24) genes. Breakpoints were also seen in 6q (three cases), 9p (two cases), or 11q23 (two cases). The following observations were made: All four chromosomally normal cases lacked TCR expression (TCR\u2013). Breakpoints at 14q11 were found in one of six TCR \u2013 cases, four of six cTCRB cases, and two of five mTCRAB cases. Abnormalities of 6q and of 9p were seen only in cases with full TCR expression (mTCRAB or mTCRGD).<\/jats:p>","DOI":"10.1002\/gcc.2870040106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:13:41Z","timestamp":1172099621000},"page":"41-45","source":"Crossref","is-referenced-by-count":9,"title":["Karyotype and T\u2010cell receptor expression in t\u2010lineage acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"4","author":[{"given":"Lorna M.","family":"Secker\u2010Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca E.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline 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