{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:17:22Z","timestamp":1791163042106,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5248,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010nine primary breast carcinomas and 11 metastases were examined to identify genetic alterations in the tumour suppressor gene regions 3p, 11p, 13q, 17p, and 17q. Loss of heterozygosity (LOH) was frequently observed on chromosome arms 17p (p144D6 lost in 75%, pYNZ22.1 in 55%, and <jats:italic>TP53<\/jats:italic> in 48% of the primary tumours), 13q (<jats:italic>RBI<\/jats:italic> lost in 40% of the primary tumours), and 17q (pRMU3 lost in 35%, pTHH59 in 29%, and <jats:italic>NM23HI<\/jats:italic> in 26% of the primary tumours). Loss of all the markers except p144D6 was observed even more frequently in the metastases. Pairwise comparisons for concordance of allele losses on 17p indicated that there might be two genes on 17p implicated in breast cancer development; the <jats:italic>TP53<\/jats:italic> gene and a gene located close to the p144D6 and pYNZ22.1 markers. LOH of the <jats:italic>RBI<\/jats:italic> gene was associated with LOH of pYNZ22.1 and p144D6, but not with LOH of <jats:italic>TP53.<\/jats:italic> LOH of <jats:italic>RBI<\/jats:italic> and <jats:italic>TP53<\/jats:italic> was associated with occurrence of ductal carcinomas, <jats:italic>RBI<\/jats:italic> and p144D6 losses with tumour size, and p144D6 losses with positive node status as well. LOH of <jats:italic>TP53<\/jats:italic> and the three 17q markers <jats:italic>NM23HI<\/jats:italic>, pTHH59, and pRMU3 was most frequently observed in tumours from postmenopausal women. p144D6 losses occurred most frequently in progesterone receptor\u2010negative tumours, whereas pTHH59 losses occurred most frequently in oestrogen receptor\u2010negative tumours. LOH of the investigated loci was not associated with <jats:italic>ERBB2<\/jats:italic> protooncogene amplification, with positive family history of breast cancer, or with survival.<\/jats:p>","DOI":"10.1002\/gcc.2870040203","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:12:45Z","timestamp":1172099565000},"page":"113-121","source":"Crossref","is-referenced-by-count":79,"title":["Genetic alterations of the tumour suppressor gene regions 3p, 11p, 13q, 17p, and 17q in human breast carcinomas"],"prefix":"10.1002","volume":"4","author":[{"given":"Tone I.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Gaustad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Lise","family":"B\u00f8rresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Farrants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jahn M.","family":"Nesland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Ottestad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell M.","family":"Tveit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3659909"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.16.4961"},{"key":"e_1_2_1_4_1","first-page":"5185","article-title":"Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential","volume":"49","author":"Bevilacqua G","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1990.334"},{"key":"e_1_2_1_6_1","first-page":"292","article-title":"Gene amplification of the neu oncogene in breast cancer tumors; correlation to loss of gene sequences on chromosome 17q. 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