{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:39:57Z","timestamp":1760981997159},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5126,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosomal aberrations involving 8q12 or 12q13\u201315 characterize two cytogenetic subgroups of salivary gland pleomorphic adenomas. As the tumors of the two groups differ in their clinical and histologic characteristics, we decided to determine their susceptibility to SV40 transformation. We transfected cell cultures from 13 adenomas with aberrations involving 8q12 and from seven adenomas with involvement of 12q13\u201315 using an SV40 plasmid coding for the early region of the viral genome. Whereas all cultures with aberrations of 12q13\u201315 showed transformed foci, only 4 of the 13 cultures with 8q12 abnormalities showed foci of transformed cells. We also observed a much higher immortalization rate in the first group (3\/7 vs. 1\/13). All successfully transformed tumor cell cultures showed a relatively stable karyotype in the pre\u2010crisis stage and a high mitotic index, were T\u2010antigen positive, and had an extended life span in vitro.<\/jats:p>","DOI":"10.1002\/gcc.2870050106","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:10:43Z","timestamp":1172099443000},"page":"35-39","source":"Crossref","is-referenced-by-count":8,"title":["Pleomorphic adenoma cells vary in their susceptibility to SV40 transformation depending on the initial karyotype"],"prefix":"10.1002","volume":"5","author":[{"given":"Bernd","family":"Kazmierczak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brita","family":"Thode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Bartnitzke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn","family":"Bullerdiek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Schloot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90100-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00123166"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890815)64:4<876::AID-CNCR2820640419>3.0.CO;2-J"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030650110"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(73)90341-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132891"},{"key":"e_1_2_1_8_1","volume-title":"Cytogenetics and Molecular Genetics of Human Solid Tumors, July 30\u2010August 1, Center for Human Genetics","author":"Kazmierczak B","year":"1990"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(80)90030-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/jvi.5.3.293-298.1970","article-title":"Comparison of transformation and T\u2010antigen induction in human cell lines","volume":"5","author":"Potter CW","year":"1970","journal-title":"J Virol"},{"key":"e_1_2_1_11_1","first-page":"415","article-title":"Pathomorphologische Subklassifikation der pleomorphen Speicheldr\u00fcsenadenome","volume":"24","author":"Seifert G","year":"1976","journal-title":"HNO"},{"key":"e_1_2_1_12_1","unstructured":"StenmanG(1983)Cytogenetic studies on human salivary gland neoplasms with special reference to chromosomal patterns in the benign mixed tumor. Thesis G\u00f6teborg."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90210-L"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.153.3741.1252"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31974"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870050106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870050106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:31:15Z","timestamp":1698067875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870050106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["10.1002\/gcc.2870050106"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870050106","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}