{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:41:41Z","timestamp":1780368101456,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5126,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The FLG\/FGFRI gene, encoding a receptor for members of the FGF family, is located at 8p 11.2\u2010p12. It is amplified, overexpressed, and not grossly rearranged in the MDA\u2010MB\u2010134 breast carcinoma cell line, whereas other genes from the pericentromeric 8p region are not amplified. The FGF4\/HSTFI gene, located at 11q13, is also amplified with a substantial portion of the 11q13 region, but is not overexpressed in MDA\u2010MB\u2010134 cells. In this cell line, amplified sequences constitute a large homogeneously staining region (HSR) which is part of a marker chromosome containing chromosome 8 and chromosome 11 sequences. Using probes for the FGF4\/HSTFI and the FLG\/FGFRI genes in fluorescence chromosomal <jats:italic>in situ<\/jats:italic> hybridization, we show that the HSR contains de novo fused and amplified 11q13 and 8p11\u2010p12 sequences associated in a complex structure containing approximately the same number of FGF4 and FGFRI genes. The significance of this genetic abnormality for MDA\u2010MB\u2010134 cells, and for breast carcinogenesis in general, is unknown, but may underlie a particular type of oncogene activation.<\/jats:p>","DOI":"10.1002\/gcc.2870050107","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:10:43Z","timestamp":1172099443000},"page":"40-49","source":"Crossref","is-referenced-by-count":30,"title":["Fusion and amplification of two originally non\u2010syntenic chromosomal regions in a mammary carcinoma cell line"],"prefix":"10.1002","volume":"5","author":[{"given":"Marina","family":"Lafage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Pedeutour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Marchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Prosperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Gaudray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Birnbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"413","article-title":"Chromosomal localization of the hst oncogene and its co\u2010amplification with the int\u20102 oncogene in a human melanoma","volume":"2","author":"Ad\u00e9la\u00efde J","year":"1988","journal-title":"Oncogene"},{"key":"e_1_2_1_3_1","first-page":"659","article-title":"BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers","volume":"6","author":"Adnane J","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870040116"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90636-D"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.3.661"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.6.2.502"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.7.1991"},{"key":"e_1_2_1_9_1","first-page":"605","article-title":"Genetics of human breast cancer","volume":"9","author":"Devilee P","year":"1990","journal-title":"Cancer Surveys"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07454.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90143-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4834"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9084(90)90161-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","unstructured":"GaudrayP SzepetowskiP EscotC BirnbaumD TheilletC(1992)DNA amplification at 11q13 in human cancer: From complexity to perplexity. 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