{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:19:08Z","timestamp":1791029948672,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5034,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schwannomas are tumors of the cranial, spinal, and peripheral nerve sheaths that originate from Schwann cells. Acoustic neurinomas are the most frequent cranial schwannomas. They might develop sporadically or in the context of neurofibromatosis type 2 (NF2). Loss of part or all of chromosome 22 is frequently found in acoustic schwannomas, suggesting that the <jats:italic>NF2<\/jats:italic> gene is a tumor suppressor gene involved in the genesis of these tumors. Only a few spinal schwannomas have been molecularly characterized so far, showing that chromosome 22 loss might also occur in these tumors. Here we present the molecular analysis of chromosome 22 in 23 acoustic schwannomas and nine schwannomas of other locations (including other cranial nerves and spinal and peripheral nerves). Most of these tumors were from sporadic cases. Multiple schwannomas of various locations were analyzed in two patients with NF2. We found partial or complete monosomy for chromosome 22 in 22% of the acoustic schwannomas and 55% of the non\u2010acoustic schwannomas. The tumors with partial monosomy included four with terminal deletions and one with a deletion of the centromeric part of the long arm of chromosome 22. The region between the \u03b2B2\u20101 crystallin locus <jats:italic>(CRYB2A)<\/jats:italic> and the myoglobin locus <jats:italic>(MB)<\/jats:italic> was commonly deleted in these tumors. Our studies suggest that a schwannoma\u2010related tumor suppressor gene within this region, which might be the <jats:italic>NF2<\/jats:italic> gene, is involved in the development of schwannomas of various locations in the nervous system. Our studies indicate that the second hit in the genesis of different schwannomas within one (predisposed) NF2 patient occurs independently and via different mechanisms.<\/jats:p>","DOI":"10.1002\/gcc.2870050305","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:09:24Z","timestamp":1172099364000},"page":"201-205","source":"Crossref","is-referenced-by-count":40,"title":["Molecular characterization of chromosome 22 deletions in schwannomas"],"prefix":"10.1002","volume":"5","author":[{"given":"Emilia K.","family":"Bijlsma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Brouwer\u2010Mladin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Andries","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries","family":"Westerveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo J. M.","family":"Hulsebos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90066-J"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90366-M"},{"key":"e_1_2_1_4_1","first-page":"5863","article-title":"Molecular genetic analysis of chromosome 22 in 81 cases of meningioma","volume":"50","author":"Dumanski JP","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290211"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90513-E"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.2.0248"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.22.6746-a"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/294536a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133080"},{"key":"e_1_2_1_11_1","first-page":"1","article-title":"Update to the Tenth International Workshop on Human Gene Mapping","volume":"55","year":"1990","journal-title":"Cytogenet Cell Genet"},{"key":"e_1_2_1_12_1","first-page":"6783","article-title":"Clonal analysis of human meningiomas and schwannomas","volume":"50","author":"Jacoby LB","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_1","first-page":"297","article-title":"A linkage and physical map of chromosome 22, and some applications to gene mapping","volume":"42","author":"Julier C","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_14_1","first-page":"783","article-title":"A t(4;22) in a meningioma points to the localization of a putative tumor\u2010suppressor gene","volume":"48","author":"Lekanne Deprez RH","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_15_1","first-page":"391","article-title":"An efficient salt\u2010chloroform extraction of DNA from blood and tissues","volume":"5","author":"M\u00fcllenbach R","year":"1989","journal-title":"Trends in Genetics"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.4.1883"},{"key":"e_1_2_1_18_1","first-page":"323","article-title":"Flanking markers bracket the Neurofibromatosis Type 2 (NF2) gene on chromosome 22","volume":"46","author":"Rouleau GA","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_19_1","first-page":"533","volume-title":"Pathology of Tumours of the Nervous System","author":"Russell DS","year":"1989"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/322644a0"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.15.5419"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3105060"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870050305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870050305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:19:32Z","timestamp":1698077972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870050305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["10.1002\/gcc.2870050305"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870050305","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}