{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:13:36Z","timestamp":1758820416558},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5003,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The disease ataxia telangiectasia (A\u2010T) is a multifaceted disorder in which patients have an increased chance of developing a T\u2010cell leukaemia, often with abnormalities of chromosome 14, but sometimes with rare translocations, like t(X; 14)(q28;q11). We describe the cloning of the breakpoint of one such novel t(X;14) from an A\u2010T patient. The translocation breaks within the T cell receptor \u03b1 chain gene on chromosome 14 at band q11 and in a region of the X chromosome, within about 1 Mb of the telomere of the long arm. The patient subsequently developed T\u2010cell prolymphocytic leukaemia (T\u2010PLL), and molecular examination showed that the tumour cells carried the same t(X; 14) breakpoint as that cloned from the premalignant cells. The same breakpoint could be detected in blood samples taken as much as 5 years prior to diagnosis of T\u2010PLL. This suggests a role for the abnormality in the tumour development in this patient but implies that other mutational events were necessary for overt disease to become manifest. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870050407","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:09:16Z","timestamp":1172099356000},"page":"321-325","source":"Crossref","is-referenced-by-count":11,"title":["Molecular analysis of a new translocation, t(X;I4)(q28;qII), in premalignancy and in leukaemia associated with ataxia telangiectasia"],"prefix":"10.1002","volume":"5","author":[{"given":"J.","family":"Thick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"Sherrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Fisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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