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They were the only clonal structural change in three tumors; in the remaining two, the clone with 3p\u2013 coexisted with seemingly unrelated clones that had other structural and numerical aberrations. The deletions were identical, del(3)(p12p14), in four cases. The fifth tumor seemed to have a smaller deletion, interpreted as del(3)(p13p14). Our findings constitute karyotypic evidence that 3p deletions are relatively common in breast carcinomas and concur with the molecular genetic detection of loss of heterozygosity in this chromosome arm. The fact that the deletions were found as solitary changes indicates that loss of genetic information from 3p loci is an early, possibly primary, event in tumorigenesis. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870060304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:44:27Z","timestamp":1172101467000},"page":"151-155","source":"Crossref","is-referenced-by-count":56,"title":["Interstitial deletion of the short arm of chromosome 3 as a primary chromosome abnormality in carcinomas of the breast"],"prefix":"10.1002","volume":"6","author":[{"given":"Nikos","family":"Pandis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuesheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Limon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Bardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Idvall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Mandahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mitelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre","family":"Heim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440115"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.23.1815"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90023-2"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90143-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90174-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90107-L"},{"key":"e_1_2_1_8_1","first-page":"37","article-title":"Cytogenetics of solid tumours","volume":"15","author":"Heim S","year":"1992","journal-title":"Recent Adv Histopathol"},{"key":"e_1_2_1_9_1","volume-title":"Guidelines for Cancer Cytogenetics, Supplement to An International System for Human Cytogenetic Nomenclature","author":"ISCN","year":"1991"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90315-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90049-G"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010304"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920401)69:7<1674::AID-CNCR2820690706>3.0.CO;2-L"},{"key":"e_1_2_1_14_1","first-page":"651","article-title":"Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell tumors","volume":"49","author":"Kovacs G","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400208"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020207"},{"key":"e_1_2_1_17_1","first-page":"954","article-title":"Cytogenetic analysis of 33 basal cell carcinomas","volume":"51","author":"Mertens F","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_1","volume-title":"Catalog of Chromosome Aberrations in Cancer","author":"Mitelman F","year":"1991"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050310"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050103"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","unstructured":"PandisN HeimS BardiG IdvallI MandahlN MitelmanF(1993)Chromosome analysis of 20 breast carcinomas: Cytogenetic multiclonality and karyotypic\u2010pathologic correlations. 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