{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:18:08Z","timestamp":1790972288382,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4822,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two\u2010color fluorescent in situ hybridizations using probes for alphoid (\u03b1) and classical satellite (CS) DNAs from chromosomes 1 and 16 were performed to characterize i(1q), der(1;16), and complex rearrangements observed in breast cancer cells from fresh tumors and established cell lines. Six of seven i(1q) occurred after breakage in the \u03b11 containing region and one of seven was dicentric, with breakage in 1p11.2. The five der(1;16)(q10;p10) studied appeared to result from a variety of breakpoints involving \u03b11, \u03b116, CS1, and CS16 DNAs. All had conserved \u03b116 DNA, suggesting a segregation of the der(1;16) leading to a loss of 16q and a gain of 1q in most cases. One complex rearrangement of chromosome 1 also appeared to involve chromosome 16, suggesting that a der(1;16) occurred first, followed by another rearrangement. Both the apparent preferential involvement of constitutive heterochromatin harboring \u03b1 and CS DNAs and the variety of breakpoints spanning along heterochromatin suggest that the important consequence of the rearrangement is not the breakage <jats:italic>per se<\/jats:italic> but the resulting imbalance. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870070103","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:42:19Z","timestamp":1172101339000},"page":"8-14","source":"Crossref","is-referenced-by-count":50,"title":["Two\u2010color FISH characterization of i(1q) and der(1;16) in human breast cancer cells"],"prefix":"10.1002","volume":"7","author":[{"given":"Nadja","family":"Kokalj\u2010Vokac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Alemeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Gerbault\u2010Seureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Malfoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dutrillaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"171","article-title":"Etude cytog\u00e9n\u00e9tique comparative de sept carcinomes d'origine mammaire","volume":"20","author":"Ayraud N","year":"1977","journal-title":"Ann Genet"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2649981"},{"key":"e_1_2_1_4_1","first-page":"24","article-title":"A new human breast carcinoma cell line with dedifferentiation characteristics in vitro and a transforming c\u2010Ki\u2010ras gene","volume":"5","author":"Calvo F","year":"1986","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_5_1","first-page":"375","volume-title":"Cytogenetics of the Mammalian X Chromosome, Part A: Basic Mechanisms of X Chromosome Behavior","author":"Couturier J","year":"1983"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90143-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01961161"},{"key":"e_1_2_1_8_1","first-page":"862","article-title":"Chromosome\u2010specific alpha satellite DNA from the centromere of human chromosome 16","volume":"45","author":"Greig GM","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_1","volume-title":"Guidelines for Cancer Cytogenetics, Supplement to An International System for Human Cytogenetic Nomenclature","author":"ISCN","year":"1991"},{"key":"e_1_2_1_10_1","first-page":"634","article-title":"A 1q12 specific repetitive human sequence related but distinct to the D1Z6 is locus D1Z1","volume":"46","author":"Jeanpierre M","year":"1987","journal-title":"Cytogenet Cell Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Kokalj\u2010VocacN AlmeidaA Viegas\u2010P\u00e9quignotE JeanpierreM MalpoyB DutrillauxB(1993) Specific induction by azacytidine of unkoiling and recombination of classical satellite containing heterochromatin. 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