{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:18:36Z","timestamp":1771010316684,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4822,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\/1p;&amp;\u20103qChromosome 11, band q23, is the frequent site of recurring cytogenetic rearrangements in human leukemia. We have cloned and sequenced the breakpoint junctions from a patient who had null\u2010cell acute lymphoblastic leukemia (ALL) with a t(11;14)(q23;q11). The chromosome 14 breakpoints occurred within the <jats:italic>TCRD<\/jats:italic> locus, close to two diversity segments. The chromosome 11 breakpoint occurred between two head\u2010to\u2010head heptamer sequences, and junctional diversity was evident at both derivative junctions, suggesting involvement of the V(D)J recombinase. The <jats:italic>TCRA\/D<\/jats:italic> locus on the normal chromosome 14 had undergone a V\u03b42\u2010D\u03b43\u2010\u03a8J\u03b1 joining. Two phage clones with this VDJ rearrangement were isolated; one of these contained an intra\u2010J\u03b1 region deletion. Two clones with the derivative 11 junction were isolated; one of these had a similar, but not identical, deletion. A heptamer\u2010nonamer recognition sequence (located \u223c70 kb 5\u2032 to C\u03b1), not associated with a <jats:italic>TCR<\/jats:italic> gene coding segment, was found in the immediate vicinity of both 5\u2032 breakpoints. We have designated this sequence 5\u2032<jats:sup>del<\/jats:sup> for 5\u2032 deleting element. An intra\u2010J\u03b1 region deletion involving this heptamer\u2010nonamer was previously identified in the leukemia cells recovered from a patient who had T\u2010cell ALL. Fifty kilobases of DNA on 11q23 surrounding the breakpoint were cloned and analyzed. No CpG islands or conserved sequences were identified within this region. Fluorescence in situ hybridization analysis showed that this 11q23 breakpoint mapped distal to the <jats:italic>MLL<\/jats:italic> gene associated with the recurring breakpoints in the 4;11, 9;11, and 11;19 translocations, distal to the <jats:italic>RCK<\/jats:italic> gene associated with an 11;14 translocation, and proximal to the <jats:italic>ETSI<\/jats:italic> gene, which is located at 11q24. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870070107","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:42:19Z","timestamp":1172101339000},"page":"38-46","source":"Crossref","is-referenced-by-count":6,"title":["Molecular analysis of a t(11;14)(q23;q11) from a patient with null\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"7","author":[{"given":"Robert C.","family":"Burnett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Rafael","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Shows","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger L.","family":"Eddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Lebeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel O.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"The RCK gene associated with t(11;14) translocation is distinct from the MLL\/ALL\u20101 gene associated with t(4;11) and t(11;19) translocations","volume":"52","author":"Akao Y","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.13.4118"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010303"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1182\/blood.V75.9.1834.1834","article-title":"High prevalence of T\u2010cell receptor V\u03b42\u2010(D)\u2010D\u03b43 or D\u03b41\/2\u2010D\u03b43 rearrangements in B\u2010precursor acute lymphoblastic leukemias","volume":"75","author":"Biondi A","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(87)90294-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1989.tb15074.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/j.1460-2075.1988.tb03040.x","article-title":"A cluster of chromosome 11p13 translocations found via distinct D\u2010D and D\u2010D\u2010J rearrangements of the human T cell receptor \u03b4 chain gene","volume":"7","author":"Boehm TL","year":"1988","journal-title":"EMBO J"},{"key":"e_1_2_1_9_1","first-page":"189","volume-title":"Advances in Cancer Research","author":"Cory S","year":"1986"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/335170a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1182\/blood.V78.11.2996.2996","article-title":"A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)","volume":"78","author":"Dub\u00e9 ID","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114193"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113453"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.7.1053"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/322843a0"},{"key":"e_1_2_1_16_1","unstructured":"KobayashiH EspinosaRIII ThirmanMJ DavisEM DiazMO Le BeauMM RowleyJD(in press) Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization. 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