{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:45:15Z","timestamp":1752360315302},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4822,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previously we have reported non\u2010random cytogenetic abnormalities involving the short arm of chromosome 9 (9p) in the majority of primary non\u2010small cell lung cancer (NSCLC) patient samples, which indicated loss of DNA sequences. In another lung tumor, pleural malignant mesothelioma (MM), cytogenetic changes also include apparent deletions of 9p. To define the location and extent of deletions of 9p in NSCLC and MM, Southern blot analyses on six NSCLC and five MM cell lines using molecular probes to 9p loci (<jats:italic>IFNA, IFNBI<\/jats:italic>, D9S3, and D9S19) were performed, and DNA dosage was determined by densitometry. Our data demonstrated reduced dosage of 9p sequences in three of six NSCLC and four of five MM lines. A homozygous deletion of D9S3 was found in one NSCLC and one MM cell line. The region of common loss overlapped the D9S3 locus and was flanked by the <jats:italic>IFNBI<\/jats:italic> and D9S19 loci. <jats:italic>IFNBI<\/jats:italic> has previously been localized to 9p22, and the D9S3 and D9S19 loci have been mapped in this study by in situ hybridization to 9p21 and 9p13, respectively. We hypothesize the existence of one or more tumor suppressor genes on 9p with a role in the development or progression of NSCLC and MM. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870070108","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:42:19Z","timestamp":1172101339000},"page":"47-53","source":"Crossref","is-referenced-by-count":30,"title":["Molecular deletion of 9p sequences in non\u2010small cell lung cancer and malignant mesothelioma"],"prefix":"10.1002","volume":"7","author":[{"given":"Rob","family":"Center","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Lukeis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Dietzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. Margaret","family":"Garson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2144057"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90086-P"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1385\/0-89603-205-1:233"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2260345"},{"key":"e_1_2_1_6_1","first-page":"5410","article-title":"Genetic alterations of the p53 gene are a feature of malignant mesotheliomas","volume":"51","author":"Cote RJ","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.14.1159"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5259"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001113220202"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133402"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90158-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2294591"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010207"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(05)80290-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/323643a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90074-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90258-C"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00327364"},{"key":"e_1_2_1_19_1","first-page":"659","article-title":"Human arbitrary fragments of genomic DNA detecting restriction fragment length polymorphisms on human chromosomes","volume":"40","author":"Icking D","year":"1985","journal-title":"Cytogenet Cell Genet"},{"key":"e_1_2_1_20_1","volume-title":"Guidelines for Cancer Cytogenetics, Supplement to an International System for Human Cytogenetic Nomenclature","author":"ISCN","year":"1991"},{"key":"e_1_2_1_21_1","first-page":"1684","article-title":"Chromosome 9 deletion mapping reveals interferon \u03b1 and interferon \u03b2\u20101 gene deletions in human glial tumors","volume":"51","author":"James CD","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1848370"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.5036"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020207"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910470219"},{"key":"e_1_2_1_26_1","first-page":"2610","article-title":"p53 and kirsten\u2010ras mutations in human mesothelioma cell lines","volume":"52","author":"Metcalf RA","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_27_1","first-page":"278","article-title":"Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons","volume":"50","author":"Miyakoshi J","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439770"},{"key":"e_1_2_1_29_1","first-page":"305","article-title":"Deletions of the short arm of chromosome 9 that include the alpha and beta interferon genes are associated with lung cancers","volume":"32","author":"Olopade OI","year":"1991","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133169"},{"key":"e_1_2_1_31_1","volume-title":"Molecular Cloning. 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