{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:55:07Z","timestamp":1758394507330},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4761,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sequence of the exon 1\/intron 1 boundary region of the <jats:italic>MYC<\/jats:italic> gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8;14) (q24;q32) and the other with t(8;22) (q24;q11). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding site in intron I, which is a frequent target for mutational inactivation in endemic Burkitt's lymphoma (eBL). The translocations at 8q24, and multiple mutations in the exon 1\/intron 1 boundary region, are reminiscent of similar findings in eBL. The same underlying oncogenic event that occurs in most eBLs is thus found in some DLCLs. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870070303","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:42:09Z","timestamp":1172101329000},"page":"128-130","source":"Crossref","is-referenced-by-count":9,"title":["Hypermutation of the <i>MYC<\/i> gene in diffuse large cell lymphomas with translocations involving band 8q24"],"prefix":"10.1002","volume":"7","author":[{"given":"John F.","family":"Bradley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Rothberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Ladanyl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S. K.","family":"Chaganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90386-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.10.5187"},{"key":"e_1_2_1_4_1","first-page":"5","article-title":"Taq DNA polymerase sequencing of double\u2010stranded amplified DNA","volume":"30","author":"Bradley JF","year":"1991","journal-title":"Promega Notes"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_1_6_1","first-page":"33","volume-title":"Cancer Cells 7: The Molecular Diagnostics of Human Cancer","author":"Chaganti RSK","year":"1989"},{"key":"e_1_2_1_7_1","first-page":"534","volume-title":"Origins of Human Cancer","author":"Dalla\u2010Favera R","year":"1991"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01816.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.10.4389"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1182\/blood.V77.5.1057.1057","article-title":"MYC rearrangement and translocations involving band 8q24 in diffuse large cell lymphoma","volume":"77","author":"Ladanyi M","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.1.74"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.9.2984"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1016\/S0021-9258(19)39597-3","article-title":"Phosphorylation\u2010dependent binding of a 138\u2010kDa myc intron factor to a regulatory element in the first intron of the c\u2010myc gene","volume":"265","author":"Zajac\u2010Kaye M","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2454510"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870070303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870070303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:12:09Z","timestamp":1698261129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870070303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/gcc.2870070303"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870070303","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}