{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:26:09Z","timestamp":1787239569824,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4761,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes & Cancer"],"published-print":{"date-parts":[[1993,7]]},"abstract":"Abstract<\/jats:title>\n \n Wilms' tumor is a childhood nephroblastoma that is postulated to arise through the inactivation of a tumor suppressor gene by a two\u2010hit mechanism. A candidate 11p13 Wilms' tumor gene,\n WTI<\/jats:italic>\n , has been cloned and shown to encode a zinc finger protein. Patients with the WAGR syndrome (Wilms' tumor, aniridia, genitourinary abnormalities, and mental retardation) have a high risk of developing Wilms' tumor and they carry constitutional deletions of one chromosome 11 allele encompassing the\n WTI<\/jats:italic>\n gene. Analysis of the remaining\n WTI<\/jats:italic>\n allele in a Wilms' tumor from a WAGR patient revealed the deletion of a single nucleotide in exon 7. This mutation likely played a key role in tumor formation, as it prevents translation of the DNA\u2010binding zinc finger domain that is essential for the function of the\n WTI<\/jats:italic>\n polypeptide as a transcriptional regulator. \u00a9 1993 Wiley\u2010Liss, Inc.\n <\/jats:p>","DOI":"10.1002\/gcc.2870070304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T18:42:09Z","timestamp":1172083329000},"page":"131-136","source":"Crossref","is-referenced-by-count":25,"title":["Homozygous inactivation of\n WTI<\/i>\n in a Wilms' tumor associated with the WAGR syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"Manfred","family":"Gessler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Qualman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Arden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Webster","family":"Cavenee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Bruns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1653","article-title":"Age distribution of Wilms' tumor: Report from the National Wilms' Tumor Study","volume":"48","author":"Breslow NE","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90601-A"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90138-9"},{"key":"e_1_2_1_5_1","first-page":"595","article-title":"Structural rearrangement of the WTI gene in Wilms' tumour cells","volume":"6","author":"Cowell JK","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80211-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000131375"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90084-0"},{"key":"e_1_2_1_9_1","first-page":"486","article-title":"A deletion map of the WAGR region on chromosome 11","volume":"44","author":"Gessler M","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/343774a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90313-H"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/336374a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.21.9618"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3247"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/336377a0"},{"key":"e_1_2_1_16_1","first-page":"997","article-title":"Evidence for WTI as a Wilms' tumor (WT) gene: Intragenic germinal deletion in bilateral WT","volume":"48","author":"Huff V","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132030"},{"key":"e_1_2_1_18_1","first-page":"313","article-title":"Mutation and cancer: A model for Wilms' tumor of the kidney","volume":"48","author":"Knudson AG","year":"1972","journal-title":"J Nat Cancer Inst"},{"key":"e_1_2_1_19_1","first-page":"711","article-title":"Familial Wiedemann\u2010Beckwith syndrome and a second Wilms' tumor locus both map to 11p15.5","volume":"44","author":"Koufos A","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_20_1","first-page":"635","article-title":"Equivalent expression of paternally and maternally inherited WTI alleles in normal fetal tissue and Wilms' tumours","volume":"7","author":"Little MH","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)52023-7"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1654597"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90129-8"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/353431a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90194-4"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.13.3753"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2244209"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.4.1799"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030203"},{"key":"e_1_2_1_30_1","first-page":"A78","article-title":"Cognition in aniridia\u2010Wilms tumor association: Analysis of karyotype associations","volume":"39","author":"Russell LJ","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_31_1","volume-title":"Molecular Cloning: A laboratory Handbook","author":"Sambrook J","year":"1989"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.5.1157"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90516-H"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870070304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870070304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T15:12:13Z","timestamp":1698246733000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870070304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/gcc.2870070304"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870070304","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}