{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:46Z","timestamp":1764688606995},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4699,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have analyzed the type of <jats:italic>MYC\/IG<\/jats:italic> heavy\u2010chain locus (<jats:italic>IGH<\/jats:italic>) rearrangement present in 15 patients affected by t(8; 14)\u2010positive primary Burkitt's lymphoma or acute lymphoblastic leukemia of the L3 type in an attempt to map in detail the locations of the chromosome 8 and chromosome 14 breakpoints. The almost constant position of the chromosome 8 breakpoint (within or immediately 5\u2032 of the <jats:italic>MYC<\/jats:italic> gene) together with two distinct clusters of breakpoints on chromosome 14 resulted in two main types of <jats:italic>MYC\/IGH<\/jats:italic> (present in 12 of 15 cases). In the first type (six cases), the <jats:italic>MYC<\/jats:italic> gene or at least its coding portion was joined with the <jats:italic>JH<\/jats:italic> region on chromosome 14, whereas in the second, present in another six cases, the <jats:italic>MYC<\/jats:italic> gene and the <jats:italic>C\u03b1l<\/jats:italic> region were juxtaposed. Physical linkage between the translocated <jats:italic>MYC<\/jats:italic> and a known enhancer element of the <jats:italic>IGH<\/jats:italic> locus is the common feature in the two types of rearrangement, suggesting that a high\u2010level constitutive expression plays a prominent role in <jats:italic>MYC<\/jats:italic> activation. Interestingly, the chromosome 14 break site within the switch \u03b1<jats:sub>1<\/jats:sub> region, which has been only occasionally described in other cases, is present in 40% of our patients, suggesting the existence of preferential breakpoint cluster regions in cases of similar geographic origin. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870080102","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:38:49Z","timestamp":1172101129000},"page":"1-7","source":"Crossref","is-referenced-by-count":32,"title":["Preferential clustering of chromosomal breakpoints in Burkitt's lymphomas and L3 type acute lymphoblastic leukemias with a t(8;14) translocation"],"prefix":"10.1002","volume":"8","author":[{"given":"Giuseppe","family":"Saglio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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Di","family":"Celle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Foa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manlio","family":"Ferrarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Roncella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina Borgna","family":"Pignatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Marradi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Izzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pierotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/321702a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3685977"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V65.1.1.1","article-title":"Molecular 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c\u2010myc rearrangement in a human leukemic T\u2010cell line","volume":"46","author":"Saglio G","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.24.7476"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1182\/blood.V77.7.1516.1516","article-title":"Pattern of chromosomal breakpoint locations in Burkitt's lymphoma: Relevance to geography and Epstein\u2010Barr virus association","volume":"77","author":"Shiramizu B","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.3.501"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood.V72.2.667.667","article-title":"Frequent c\u2010myc oncogene activation and infrequent presence of Epstein\u2010Barr virus genome in AIDS associated lymphoma","volume":"72","author":"Subar 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