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We used comparative genomic hybridization to identify the amplified sequences presumed to represent the dmin of the leukemic cells; the tumor\/normal ratios indicated increased signal intensity at 8q24. This localization prompted investigation by semi\u2010quantitative PCR that revealed amplification of the MYC oncogene. The extent of chromosome aberrations and the oncogene amplification, both linked with poor prognosis, may relate to the rapid course of this patient's disease. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870080308","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:38:39Z","timestamp":1172101119000},"page":"185-189","source":"Crossref","is-referenced-by-count":40,"title":["Extrachromosomal gene amplification in acute myeloid leukemia; Characterization by metaphase analysis, comparative genomic hybridization, and semi\u2010quantitative PCR"],"prefix":"10.1002","volume":"8","author":[{"given":"A. 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