{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:02:27Z","timestamp":1790917347094,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4546,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have established two cell lines, PER\u2010452 and PER\u2010453, from an 8\u2010month\u2010old girl with an extensive pineoblastoma. Characterization of these lines revealed that the proto\u2010oncogenes <jats:italic>MYC<\/jats:italic> and <jats:italic>MYCN<\/jats:italic> were not amplified, but both cell lines showed <jats:italic>MYCN<\/jats:italic> expression comparable to a cell line with 200\u2010fold <jats:italic>MYCN<\/jats:italic> amplification. Both cell lines contained an i( 17q). These results support the concept that pineoblastomas belong to a larger group of primitive neuroectodermal tumors of the central nervous system. These two cell lines provide a unique opportunity to investigate the molecular genetic mechanisms underlying these neoplasms further. <jats:italic>Genes Chrom Cancer<\/jats:italic> 9:129\u2010135 (1994).\u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870090209","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:44:47Z","timestamp":1172101487000},"page":"129-135","source":"Crossref","is-referenced-by-count":30,"title":["Enhanced MYCN expression and lsochromosome 17q in pineoblastoma cell lines"],"prefix":"10.1002","volume":"9","author":[{"given":"Ursula R.","family":"Kees","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela R.","family":"Ranford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne E.","family":"Peroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn A.","family":"Biegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette H.","family":"Parmiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia A.","family":"Hallam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L. 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