{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:18:29Z","timestamp":1758709109771},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4518,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translocations involving chromosome band 11q23 are found in both lymphoid and myeloid leukemias as well as in lymphomas, and we have recently reported that rearrangement of the <jats:italic>MLL<\/jats:italic> gene is involved in these translocations. The chromosomes most frequently involved in reciprocal translocations include chromosomes 4, 6, 9, and 19, and we and others have reported that chromosomes 1, 2, 10, 15, 17, 18, 22, and X are also involved. In the cell line Karpas 45, which has a t(X;II) (q13;q23) translocation, we report here that the <jats:italic>MLL<\/jats:italic> gene is rearranged and that there are two altered transcripts of <jats:italic>MLL<\/jats:italic> that come from the der(11) chromosome. <jats:italic>Genes Chrom Cancer<\/jats:italic> 9:221\u2010224 (1994). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870090311","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:16:42Z","timestamp":1172103402000},"page":"221-224","source":"Crossref","is-referenced-by-count":12,"title":["DNA rearrangements and altered transcripts of the MLL gene in a human T\u2010all cell line karpas 45 with a t(X;II) (q13;q23) translocation"],"prefix":"10.1002","volume":"9","author":[{"given":"Norah R.","family":"McCabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Kipiniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thirman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel O.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"6083","article-title":"The RCKgene associated with t(11;14) translocation is distinct from the MLL\/ ALL\u20101 gene with t(4;11) and t(11;19) translocations","volume":"52","author":"Akao Y","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","first-page":"6712","article-title":"Cloning of ALL\u20101, the locus involved in leukemias with the t(4;11) (q21;q23), t(9;11) (p22;q23), and t(11;19) (q23;p13) chromosome translocations","volume":"51","author":"Cimino G","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1092-113"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90522-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90603-A"},{"key":"e_1_2_1_7_1","volume-title":"Cancer Cytogenetics","author":"Heim S","year":"1987"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(77)90063-7"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1182\/blood.V80.7.1659.1659","article-title":"Chromosome 11q23 translocations in both infant and adult acute leukemias are detected by in situ hybridization with a yeast artificial chromosome","volume":"80","author":"Kearney L","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_10_1","first-page":"547","article-title":"Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization","volume":"82","author":"Kobayashi H","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.8.1967"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.11794"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133721"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3738"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38926-4"},{"key":"e_1_2_1_16_1","first-page":"3816","article-title":"Molecular cytogenetics: Rosetta Stone for understanding cancer (Twenty\u2010ninth G.H.A.Clowes Memorial Award Lecture)","volume":"50","author":"Rowley JD","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050316"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90602-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309233291302"},{"key":"e_1_2_1_20_1","first-page":"479","article-title":"Gene rearrangement and truncated mRNA in cell lines with 11q23 translocation","volume":"8","author":"Yamamoto K","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10735"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870090311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870090311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T04:58:31Z","timestamp":1698123511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870090311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1002\/gcc.2870090311"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870090311","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]}}}