{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:13:22Z","timestamp":1791263602486,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4487,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The variant translocation t(8;22) in Burkitt's lymphoma (BL) cells joins band q24 of chromosome 8 distal to the proto\u2010oncogene\n                    <jats:italic>MYC<\/jats:italic>\n                    to the immunoglobulin lambda locus. The distribution of breakpoints on chromosome 8 of 11 cell lines with t(8;22) has been investigated by in situ fluorescence hybridization and pulsed\u2010field gel electrophoresis. We show that these chromosomal breakpoints generally fall within a region of about 300 kb 3\u2032 of\n                    <jats:italic>MYC<\/jats:italic>\n                    and that at least 8 out of 11 affect the previously characterized transcriptional unit\n                    <jats:italic>PVT1<\/jats:italic>\n                    . Comparable results were obtained in earlier experiments analyzing the variant t(2;8). Recently, in a series of BL cells carrying t(8;14), breakpoints upstream of\n                    <jats:italic>MYC<\/jats:italic>\n                    have been described at a similar distance. Therefore, our results suggest that deregulation of\n                    <jats:italic>MYC<\/jats:italic>\n                    by the immunoglobulin loci can occur at a distance of up to about 350 kbp of\n                    <jats:italic>MYC. Genes Chrom Cancer 9:282\u2010287 (1994).<\/jats:italic>\n                    \u00a9 1994 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/gcc.2870090408","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T19:16:37Z","timestamp":1172085397000},"page":"282-287","source":"Crossref","is-referenced-by-count":77,"title":["Breakpoints of burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC"],"prefix":"10.1002","volume":"9","author":[{"given":"Reinhard","family":"Zeidler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Joos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri\u2010Jacques","family":"Delecluse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg W.","family":"Bornkamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Klobeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Vuillaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert M.","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6414084"},{"key":"e_1_2_1_4_1","first-page":"2263","article-title":"A new variant 15;16 translocation in mouse plasmacytomas leads to the juxtaposition of c\u2010mycand immunoglobulin lambda","volume":"6","author":"Axelson H","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_5_1","unstructured":"BernhardtG(1991)Untersuchungen zum Differenzierungsgrad von Burkitt Lymphom\u2010Zellen anhand der Analyse funktionaler und aberranter tumorspezifischer Immunglobuline. Thesis. Ludwig\u2010Maximilians\u2010Universit\u00e4t M\u00fcnchen."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"21183","DOI":"10.1016\/S0021-9258(19)30064-X","article-title":"Immunoglobulin k expression after stable integration","volume":"264","author":"Blasquez VC","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_1_7_1","first-page":"223","volume-title":"Cellular Oncogene Activation","author":"Bornkamm GW","year":"1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1073\/pnas.81.7.1991","article-title":"Genomic sequencing","volume":"81","author":"Church GM","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_1_9_1","first-page":"235","article-title":"B\u2010cell maturation stages of Burkitt's lymphoma cell lines according to Epstein\u2010Barr virus status and type of chromosome translocation","volume":"78","author":"Cohen J","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830210627"},{"key":"e_1_2_1_11_1","first-page":"188","article-title":"Activation of cellular oncogenes by chromosomal translocations","volume":"47","author":"Cory S","year":"1986","journal-title":"Adv Cancer Res"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/j.1460-2075.1985.tb03682.x","article-title":"Variant t(6; 15) translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c\u2010myconcogene","volume":"4","author":"Cot S","year":"1985","journal-title":"EMBO J"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.11.3199"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910330407"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.3.820"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90418-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300311"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04578.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/314740a0"},{"key":"e_1_2_1_21_1","unstructured":"HengleinB(1988)Ein Bruchpunktcluster der Translokationen t(2;8) beim Burkitt\u2010Lymphom. Thesis. Albert\u2010Ludwigs\u2010Univer\u2010sit\u00e4t Freiburg i. Br."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.2105"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/294536a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/307752a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.8.625"},{"key":"e_1_2_1_26_1","first-page":"6547","article-title":"Mapping chromosomal breakpoints of Burkitt's t(8;14) translocations far upstream of c\u2010myc","volume":"52","author":"Joos S","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.10.4751"},{"key":"e_1_2_1_28_1","first-page":"158","article-title":"Correlation between immunoglobulin light chain expression and variant translocation in Burkitt lymphoma","volume":"324","author":"Lenoir G","year":"1982","journal-title":"Nature"},{"key":"e_1_2_1_29_1","first-page":"309","volume-title":"Burkitt's Lymphoma: A Human Cancer Model","author":"Lenoir GM","year":"1985"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2294592"},{"key":"e_1_2_1_31_1","first-page":"162","article-title":"Possible role of immunoglobulin recombination sequences in the genesis of variant t(2;8) translocations in Burkia lymphoma","volume":"132","author":"Lipp M","year":"1986","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60470-4"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6316501"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90111-1"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02458.x"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3257"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/302445a0"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870090408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870090408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T21:57:37Z","timestamp":1698098257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870090408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1002\/gcc.2870090408"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870090408","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}