{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:27:45Z","timestamp":1765700865535},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4396,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre\u2010B cell leukemia and results in the formation of a fusion gene E2A\u2010PBXI that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia\/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the <jats:italic>E2A<\/jats:italic> gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)\u2010positive lymphoma\/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre\u2010B cell leukemia. Genes Chromosom Cancer 10:171\u2013176 (1994). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870100304","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:48:44Z","timestamp":1172101724000},"page":"171-176","source":"Crossref","is-referenced-by-count":8,"title":["t(1;19) without detectable <i>E2A<\/i> rearrangements in two t(14; 18)\u2010positive lymphoma\/leukemia cases"],"prefix":"10.1002","volume":"10","author":[{"given":"Iwona","family":"Wlodarska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Stul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"De Wolf\u2010Peeters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Verhoef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mecucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Jacques","family":"Cassiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman","family":"Van Den Berghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(85)80070-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.4.1086.1086"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7439"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90381-6"},{"key":"e_1_2_1_7_1","first-page":"535","article-title":"Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22)","volume":"6","author":"Griffin TC","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/348334a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1182\/blood.V77.4.687.687","article-title":"The t(1;19)(q32;p13) results in consistent fusion of E2A and PBXI coding sequences in acute lymphoblastic leukemias","volume":"77","author":"Hunger SP","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_10_1","volume-title":"Guidelines for Cancer Cytogenetics. Supplement to an International System for Human Genetic Nomenclature","author":"ISCN","year":"1991"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90658-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90174-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2799390"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020313"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407193110318"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90657-Z"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood.V79.7.1781.1781","article-title":"Different molecular consequences of the 1;19 chromosomal translocation in childhood B\u2010cell precursor acute lymphoblastic leukemia","volume":"79","author":"Privitera E","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_18_1","first-page":"2155","article-title":"Isochromosome i(22q\u2014) confirmed by in situ hybridization of v\u2010abl gene in a case of CML in blast crisis","volume":"27","author":"Takimoto Y","year":"1986","journal-title":"Jpn J Clin Haematol"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020211"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6093263"},{"key":"e_1_2_1_21_1","first-page":"36","article-title":"Molecular investigation of 19p13 in standard and variant translocations: The E12 probe recognizes the 19p13 breakpoint in cases with t(1;19) and acute leukemia other than pre\u2010B immu\u2010nophenotype","volume":"5","author":"Yamada T","year":"1991","journal-title":"Leukemia"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870100304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870100304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T17:48:50Z","timestamp":1698169730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870100304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/gcc.2870100304"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870100304","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}