{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:50:46Z","timestamp":1698213046750},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4396,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe chromosome abnormalities in 6 patients with hairy cell leukaemia (HCL) variant, a rare B\u2010cell disorder with clinical and laboratory features intermediate between HCL and B\u2010prolymphocytic leukaemia (B\u2010PLL). All but one had marked splenomegaly and a raised white blood cell count (median 40 \u00d7 10<jats:sup>9<\/jats:sup>\/l) with over 80% nucleolated hairy cells. These cells had a B\u2010cell immunophenotype distinct from that of typical HCL. All patients but one are alive with stable disease with a median follow\u2010up of 60 months. Numerical chromosome changes included loss of chromosomes 2, 3, 4, 6, 10, 19, 21, and X. Three cases had translocations involving the immunoglobulin gene regions: t(14;17)(q32;q11), t(14;22)(q32;q11), and t(2;8)(p11.12;q24). Immunocytochemistry demonstrated the presence of the MYC protein in cells from the case with t(2;8) but not in two others. Other structural abnormalities included t(3;10)(q27;q22) and t(3;12)(q27;q13) in the same patient, der(17)t(7;10;17) (p11;q27;q22), t(1;3)(q25;p21), t(8;21)(p12;q11), t(17;21)(p11;p11), del(6)(q15), del(7)(q34), and del(14)(q24). Genes Chromosom Cancer 10:197\u2013202 (1994). \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870100308","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:48:44Z","timestamp":1172101724000},"page":"197-202","source":"Crossref","is-referenced-by-count":16,"title":["Chromosome abnormalities in hairy cell leukaemia variant"],"prefix":"10.1002","volume":"10","author":[{"given":"Vasantha","family":"Brito\u2010Babapulle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Oscier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(86)90035-4"},{"key":"e_1_2_1_3_1","first-page":"27","article-title":"Cytogenetic studies on prolymphocytic leukemia","volume":"1","author":"Brito\u2010Babapulle V","year":"1987","journal-title":"Hematol Pathol"},{"key":"e_1_2_1_4_1","first-page":"83","article-title":"Translocations t(14;18) and t(8;14) with rearranged BCL\u20102 and C\u2010MYC in a case presenting as B\u2010ALL (L3)","volume":"5","author":"Brito\u2010Babapulle V","year":"1991","journal-title":"Leukemia"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050210"},{"key":"e_1_2_1_6_1","unstructured":"BrizardM LessardM BrizardF ValensiF JaquenE GullhotF FlandrinG TanzerJ(1993) Hairy cell leukaemia variant (HCLV): Chromosomal abnormalities in 2 patients. Am Soc Hematol Meeting St. Louis MO (Abstr)."},{"key":"e_1_2_1_7_1","first-page":"156","volume-title":"The Lymphoid Leukaemias","author":"Catovsky D","year":"1990"},{"key":"e_1_2_1_8_1","first-page":"362","article-title":"Hairy cell leukemia (HCL) variant: An intermediate disease between HCL and B\u2010prolymphocytic leukemia","volume":"11","author":"Catovsky D","year":"1984","journal-title":"Sem Oncol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(80)90066-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/32.2.6198355"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.5.1.114"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-5-677"},{"key":"e_1_2_1_13_1","first-page":"522","volume-title":"Catalog of Chromosome Aberrations in Cancer","author":"Mitelman F","year":"1991"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1993.tb03337.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711660304"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.1.157.157"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.8.8.3080"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711600404"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870100308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870100308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T17:49:21Z","timestamp":1698169761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870100308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/gcc.2870100308"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870100308","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}