{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:11Z","timestamp":1761058631945},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have used fluorescence in situ hybridisation (FISH) with a series of yeast artificial chromosome (YAC) clones that map to the long arm of chromosome 6 (6<jats:italic>q<\/jats:italic>) to define the region(s) of deletion in seven cases of non\u2010Hodgkin's lymphoma (NHL), in which a deletion of 6q had been detected by conventional cytogenetics. The FISH analysis detected two regions of deletion: (i) A proximal region flanked by <jats:italic>M6PI<\/jats:italic> (6q 14\u201315) and <jats:italic>FYN<\/jats:italic> (6q21), containing D6S246, which was missing in all seven cases. This locus was also found to be deleted in all six cases of acute lymphoblastic leukaemia (ALL) studied previously, (ii) A second region of 6q, which was distal to 6q23.1 (D6S238) and included <jats:italic>ESR<\/jats:italic> (6q25.l) and D6S281 (6q27), which was shown to be present in all our cases of ALL, was found to be deleted in 4 of the 7 cases of NHL. Our results support the suggestion that tumour suppressor genes, involved in the pathogenesis of lymphoid malignancies, may be present within these regions. <jats:italic>Genes Chromosom Cancer 10:286\u2013288 (1994).<\/jats:italic> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870100411","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:48:44Z","timestamp":1172101724000},"page":"286-288","source":"Crossref","is-referenced-by-count":50,"title":["Common region of deletion on the long arm of chromosome 6 in non\u2010Hodgkin's lymphoma and acute lymphoblastic leukaemia"],"prefix":"10.1002","volume":"10","author":[{"given":"Lia P.","family":"Menasce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Orphanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Santibanez\u2010Koref","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.8.1951"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195819"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90025-A"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.7.1781.1781"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","unstructured":"MenasceLP OrphanosV Santibanez\u2010KorefM BoyleJM HarrisonCJ(1993a) Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia. Genes Chrom Cancer in press.","DOI":"10.1002\/gcc.2870100105"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1320"},{"key":"e_1_2_1_8_1","volume-title":"Catalog of Chromosome Aberrations in Cancer, 4th ed","author":"Mitelman F","year":"1991"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1182\/blood.V82.7.2157.2157","article-title":"6q deletions define distinct clinico\u2010pathological subsets of non\u2010Hodgkin's lymphoma","volume":"82","author":"Offit K","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_10_1","first-page":"449","article-title":"Chromosomal localization of the human FYN gene","volume":"1","author":"Popescu NC","year":"1987","journal-title":"Oncogene"},{"key":"e_1_2_1_11_1","first-page":"5815","article-title":"Fine\u2010scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers","volume":"52","author":"Saito S","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/359794a0"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870100411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870100411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T01:09:49Z","timestamp":1698196189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870100411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,8]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,8]]}},"alternative-id":["10.1002\/gcc.2870100411"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870100411","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,8]]}}}