{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:49:38Z","timestamp":1698212978132},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nearly all mouse plasmacytomas (MPCs) carry an <jats:italic>Ig\/myc<\/jats:italic> translocation. Any one of the three <jats:italic>lg<\/jats:italic> loci may participate, while the <jats:italic>myc<\/jats:italic> contribution has been limited to <jats:italic>c\u2010myc<\/jats:italic>, excluding other members of the <jats:italic>myc<\/jats:italic> gene family. The same is true for the other two known <jats:italic>lg\/myc<\/jats:italic> translocation\u2010carrying tumors, Burkitt's lymphoma and rat immunocytoma. It is believed that the <jats:italic>lg\/myc<\/jats:italic> juxtaposition plays a decisive, rate limiting role in the genesis of the three tumors, acting through the constitutive activation of <jats:italic>myc<\/jats:italic> that makes it refractory to normal regulation. Here we describe the molecular analysis of a unique t(6;12)(CI;B) translocation that we previously identified in an exceptional MPC that expressed <jats:italic>N\u2010myc<\/jats:italic> but not <jats:italic>c\u2010myc.<\/jats:italic> We now show that the translocation led to the juxtaposition of <jats:italic>N\u2010myc<\/jats:italic> and <jats:italic>lgx<\/jats:italic>. This is the first case of an <jats:italic>lg\/myc<\/jats:italic>\u2010carrying tumor that involves <jats:italic>N\u2010myc<\/jats:italic> rather than <jats:italic>c\u2010myc<\/jats:italic>. These findings suggest that the translocation may already have occurred at the pro\u2010 or pre\u2010B cell stage at which <jats:italic>N\u2010myc<\/jats:italic> is open for transcription. According to this interpretation, constitutive activation of <jats:italic>N\u2010myc<\/jats:italic> would suppress the expression of <jats:italic>c\u2010myc<\/jats:italic>, but would not interfere with the differentiation of the pro\u2010B cell into a fully mature plasma cell. Its tumorigenic influence would become manifest only at the time when the cell would normally be programmed to leave the cycling compartment, in connection with its terminal differentiation.<\/jats:p>","DOI":"10.1002\/gcc.2870110204","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:47:54Z","timestamp":1172101674000},"page":"85-90","source":"Crossref","is-referenced-by-count":3,"title":["Juxtaposition of <i>N\u2010myc<\/i> and <i>Igk<\/i> through a reciprocal t(6;12) translocation in a mouse plasmacytoma"],"prefix":"10.1002","volume":"11","author":[{"given":"H\u00e5kan","family":"Axelson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yisong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Geneni\u00e8ve","family":"Mattei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/318533a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3317825"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.16.6333"},{"key":"e_1_2_1_5_1","first-page":"2263","article-title":"A new variant 15;16 translocation in mouse plasmacytoma leads to the juxtaposition of c\u2010myc and Ig lambda","volume":"6","author":"Axelson H","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-77633-5_40"},{"key":"e_1_2_1_7_1","first-page":"188","article-title":"Activation of cellular oncogenes in hematopoetic cells by chromosome translocation","volume":"47","author":"Cory S","year":"1986","journal-title":"Adv Cancer Res"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1985.tb03682.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.1Part1.387"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03482.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.11.3746"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90381-6"},{"key":"e_1_2_1_13_1","first-page":"275","article-title":"Mapping of Nmyc\u20101 to mouse chromosome 12, band A3\/B","volume":"89","author":"Klett C","year":"1991","journal-title":"Mouse Genome"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.6.1717"},{"key":"e_1_2_1_15_1","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Maniatis T","year":"1982"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293038"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1016\/S0021-9258(19)69374-9","article-title":"The nuclcoride sequence of a 5.5 kb DNA segment containing the mouse kappa immunoglobulin J and C region genes","volume":"256","author":"Max EE","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0021-9258(19)70080-5","article-title":"Mouse actin messenger RNAs. Construction of a recombinant molecule containing a complementary DNA transcript of mouse alpha\u2010actin mRNA","volume":"256","author":"Minty AJ","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.19.7376"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910490214"},{"key":"e_1_2_1_21_1","first-page":"251","article-title":"An exceptional mouse plasmacytoma with a new kappa\/N\u2010myc (T6;12)(C1;B) translocation expresses N\u2010myc but not c\u2010myc","volume":"182","author":"Silva S","year":"1992","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.4.1578"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/303401a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440227"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/302575a0"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/301425a0"},{"key":"e_1_2_1_27_1","first-page":"1241","article-title":"Functional homology between N\u2010myc and c\u2010myc in plasmacytomagenesis: Plasmacytoma development in N\u2010myc transgenic mice","volume":"7","author":"Wang Y","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/312777a0"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3014659"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(93)90610-F"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/319780a0"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870110204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870110204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T03:48:30Z","timestamp":1698119310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870110204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1002\/gcc.2870110204"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870110204","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}