{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:54:14Z","timestamp":1760853254219},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4243,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In B\u2010cell malignancies, the t(11;14)(q13;q32) at the 11q13 <jats:italic>BCLI<\/jats:italic> locus is characterized by a scattering of breakpoint sites along a 100 kb genomic region, between the <jats:italic>BCLI<\/jats:italic> major translocation cluster (MTC) and the <jats:italic>PRADI<\/jats:italic> (also termed <jats:italic>cyclin DI<\/jats:italic> or <jats:italic>CCNDI<\/jats:italic>) gene. Recently, the 11q13 breakpoint region was extended on both sides, centromeric to the MTC and telomeric to <jats:italic>PRADI.<\/jats:italic> We report here the molecular cloning of a new t(11;14) breakpoint site, 20 kb centromeric to the MTC, from a patient with prolymphocytic leukemia. We subcloned a non\u2010repetitive DNA fragment near the breakpoint and mapped this new 11q13 probe (pHOII<jats:sub>c<\/jats:sub>) relative to already identified breakpoint sites, using long\u2010 and short\u2010range physical mapping within the <jats:italic>BCLI<\/jats:italic> locus. Rearrangements in the <jats:italic>BCLI<\/jats:italic> locus are associated with deregulation of the <jats:italic>PRADI<\/jats:italic> gene, which is often overexpressed, particularly in mantle\u2010cell malignancies. The detectable but weak <jats:italic>PRADI<\/jats:italic> expression in the case we present suggests that this breakpoint centromeric to the MTC still lies inside the <jats:italic>BCLI<\/jats:italic> locus boundaries. We think that attention should be focused on this region centromeric to the <jats:italic>BCLI<\/jats:italic>\u2010MTC, where the investigation of previously unidentified translocations may increase understanding of the <jats:italic>PRADI<\/jats:italic> gene deregulation in t(11;14) associated pathologies.<\/jats:p>","DOI":"10.1002\/gcc.2870110407","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:46:50Z","timestamp":1172101610000},"page":"246-255","source":"Crossref","is-referenced-by-count":15,"title":["Molecular cloning of a t(11; 14)(q13;q32) translocation breakpoint centromeric to the <i>BCLI<\/i>\u2010MTC"],"prefix":"10.1002","volume":"11","author":[{"given":"Sylvie","family":"Gali\u00e8gue\u2010Zouitina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud","family":"Collyn\u2010d'Hooghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Denis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Mainardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Paule","family":"Hildebrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Tilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bastard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Kerckaert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1111","article-title":"Frequent 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