{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:08:54Z","timestamp":1764781734213},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Beckwith\u2010Wiedemann syndrome (BWS) is a congenital overgrowth disorder with a varying spectrum of clinical manifestations including macroglossia, omphalocele, hemihypertrophy, and a predisposition to a subset of embryonal tumors, most frequently Wilms' tumor (WT). A variety of cytogenetic, genetic linkage, and molecular mapping data implicate a gene or genes on chromosome band 11p15.5 in BWS and its related tumors. However, some families with BWS do not show linkage to 11p15, and other alterations have been found in Wilms' tumors as well. One such alteration is loss of heterozygosity (LOH) for chromosome arm 16q. Here we have analyzed a balanced t(11;16)(p15;q13) chromosomal translocation associated with the BWS phenotype and mapped the breakpoint positions for both chromosomes 11 and 16 by using somatic cell hybrids and polymorphic markers. The chromosome 11 breakpoint was found to lie distal to the D11S12 locus, but proximal to <jats:italic>TH<\/jats:italic> on 11p15.5, a region shown previously to contain other BWS\u2010related chromosomal events. The chromosome 16 breakpoint was distal to D16S290 in 16q13, but proximal to loci D16S265, D16S267, and D16S164 in band 16q21. This area encompasses the region of LOH occurring through mitotic recombination in sporadic WT. This raises interesting possibilities for the genetic and epigenetic involvement of both chromosomal regions (11p15 and 16q13) in the pathogenesis of BWS and Wilms' tumor.<\/jats:p>","DOI":"10.1002\/gcc.2870120102","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:14:23Z","timestamp":1172103263000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["A constitutional bws\u2010related t(11;16) chromosome translocation occurring in the same region of chromosome 16 implicated in wilms' tumors"],"prefix":"10.1002","volume":"12","author":[{"given":"Irene","family":"Newsham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kindler\u2010R\u00f6hrborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Daub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Webster","family":"Cavenee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.20.5793"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050408"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1656527"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/362751a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/336374a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000472384"},{"key":"e_1_2_1_8_1","first-page":"6117","article-title":"Nonlinkage of 16q markers to familial predisposition to Wilms' tumor","volume":"52","author":"Huff V","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274150"},{"key":"e_1_2_1_10_1","first-page":"5376","article-title":"Chromosome abnormalities in tumor cells from patients with sporadic Wilms' tumor","volume":"44","author":"Kondo K","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","first-page":"711","article-title":"Familial Wiedemann\u2010Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5","volume":"44","author":"Koufos A","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280564"},{"key":"e_1_2_1_13_1","first-page":"3279","article-title":"Loss of heterozygosity in Wilms' tumors, studied for six putative tumor suppressor regions, is limited to chromosome 11","volume":"50","author":"Mannens M","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","first-page":"3094","article-title":"A third Wilms' tumor locus on chromosome 16q","volume":"52","author":"Maw MA","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(84)90214-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1091"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/362749a0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-94"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282078"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.24.6964"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/329645a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.9.1505"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90071-F"},{"key":"e_1_2_1_24_1","first-page":"255","article-title":"Neoplasms associated with the Beckwith\u2010Wiedemann syndrome","volume":"3","author":"Sotel\u2010Avila D","year":"1976","journal-title":"Perspec Pediatr Pathol"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90260-Y"},{"key":"e_1_2_1_26_1","first-page":"901","article-title":"Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11","volume":"5","author":"Wadey RB","year":"1990","journal-title":"Oncogene"},{"key":"e_1_2_1_27_1","first-page":"2780","article-title":"Chromosome analysis of 31 Wilms' tumors","volume":"50","author":"Wang\u2010Wuu S","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.13.4034"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093-143"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.5.549"},{"key":"e_1_2_1_31_1","first-page":"4486","article-title":"Refinement of regional loss of heterozygosity for chromosome 11p15.5 in human breast tumors","volume":"53","author":"Winqvist R","year":"1993","journal-title":"Cancer Res"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870120102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870120102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:45:15Z","timestamp":1698252315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870120102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/gcc.2870120102"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870120102","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}