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The absence of 12p material in structural rearrangements was confirmed by chromosome painting. In the two tumors the following common chromosomal breakpoints were found: 6p21, 6p22, 6q23, and 11q13. Exactly the same chromosomal regions, 6p22::6q23 and 6p21::11q13, were involved in fusions. The two tumors belong to a new entity of extragonadal immature teratomas of adults which may be located in the retroperitoneum and posterior mediastinum and are prone to blood borne metastasis.<\/jats:p>","DOI":"10.1002\/gcc.2870120103","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:14:23Z","timestamp":1172103263000},"page":"8-15","source":"Crossref","is-referenced-by-count":22,"title":["Definition of a new entity of malignant extragonadal germ cell tumors"],"prefix":"10.1002","volume":"12","author":[{"given":"Jannie","family":"van Echten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bauke","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Sinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00ebl Olde","family":"Weghuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk Th.","family":"Sleijfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wolter Oosterhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870060112"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91557-4"},{"key":"e_1_2_1_4_1","first-page":"5696","article-title":"Chromosomal changes in primary testicular non\u2010seminomatous germ cell tumors","volume":"49","author":"Castedo SMMJ","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010113"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90025-A"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(89)90092-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-65857-0_2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92922-9"},{"key":"e_1_2_1_10_1","first-page":"1542","article-title":"Isochromosome (12p) positive intracranial germ cell teratatoma","volume":"54","author":"De Bruin TWA","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90115-Q"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1987.tb00164.x"},{"key":"e_1_2_1_13_1","series-title":"Atlas of Tumor Pathology. 2nd series","volume-title":"Extragonadal Teratomas","author":"Gonzales\u2010Crussi F","year":"1982"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132934"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90134-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870090409"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90136-0"},{"key":"e_1_2_1_18_1","first-page":"321","article-title":"Cytogenetics, ploidy and differentiation of human testicular, ovarian and extragonadal germ cell tumors","volume":"9","author":"Oosterhuis JW","year":"1990","journal-title":"Cancer Surv"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90206-A"},{"key":"e_1_2_1_20_1","first-page":"2285","article-title":"Cytogenetic analysis of 124 prospectively ascertained male germ cell tumors","volume":"52","author":"Rodriguez E","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010406"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90249-A"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(94)90176-7"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1987.tb00161.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910290212"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/50.1.235"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90155-9"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90056-E"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90173-J"},{"key":"e_1_2_1_30_1","first-page":"635","article-title":"Genetics and biology of human ovarian teratoma. 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