{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:06:08Z","timestamp":1790697968200,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral T\u2010cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the \u03b3\/\u03b4 T\u2010cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non\u2010Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T \u03b3\/\u03b4 cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T \u03b3\/\u03b4 PTL.<\/jats:p>","DOI":"10.1002\/gcc.2870120302","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:13:34Z","timestamp":1172103214000},"page":"161-164","source":"Crossref","is-referenced-by-count":102,"title":["Consistent presence of isochromosome 7q in hepatosplenic t \u03b3\/\u03b4 lymphoma: A new cytogenetic\u2010clinicopathologic entity"],"prefix":"10.1002","volume":"12","author":[{"given":"Chuan\u2010Cheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwei\u2010Fang","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tseh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ih\u2010Jen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiu\u2010Hwa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sou\u2010Ming","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Ching","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3672118"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470953"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.4049\/jimmunol.138.5.1502","article-title":"Characterization 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