{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T14:12:48Z","timestamp":1698415968902},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a family with a constitutional translocation t(3;6), the oldest member carrying the translocation had developed multiple nonpapillary renal cell carcinomas (RCCs). The translocation breakpoint was positioned between 3p13 and 3p14.1. This is close to the region in which a t(3;8) breakpoint has been reported in a family with hereditary RCC. We defined the location of the t(3;6) and t(3;8) breakpoints by fluorescence in situ hybridization (FISH) analysis with yeast artificial chromosomes (YACs) from the 3p14\u201313 region. Both interphase nuclei and metaphase cells from translocation\u2010carrying members of both families have been used, allowing the definition of flanking YACs for each breakpoint. We could thereby clearly confirm that the breakpoints are different, the t(3;8) breakpoint being most distal. In addition, we have shown that both translocation breakpoints are located distal to the homozygously deleted region in the U2020 lung cancer cell line.<\/jats:p>","DOI":"10.1002\/gcc.2870120311","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:13:34Z","timestamp":1172103214000},"page":"224-228","source":"Crossref","is-referenced-by-count":9,"title":["Defining the position of the breakpoint of the constitutional t(3;6) occurring in a family with renal cell carcinoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Anke","family":"van den Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke Y.","family":"van der Veen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam M. F.","family":"Hulsbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Gemmill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry A.","family":"Drabkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H. C. M.","family":"Buys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8509"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"BoldogFL WaggonerB GloverTW ChumakovI Le PaslierD CohenD GemmillRM DrabkinHA(1994)An integrated YAC contig containing the 3p14. 2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B. 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Genomics (in press).","DOI":"10.1016\/0888-7543(95)80105-U"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90060-R"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(84)90028-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1390"},{"key":"e_1_2_1_19_1","first-page":"4707","article-title":"A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma","volume":"51","author":"Yamakawa K","year":"1991","journal-title":"Cancer Res"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870120311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870120311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:32:46Z","timestamp":1698287566000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870120311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/gcc.2870120311"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870120311","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}