{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:08Z","timestamp":1761058628003},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4031,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes & Cancer"],"published-print":{"date-parts":[[1995,7]]},"abstract":"Abstract<\/jats:title>Pheochromocytomas occur sporadically and are associated with several dominantly inherited cancer syndromes, including von Hippel\u2010Lindau (VHL) disease. We examined 14 pheochromocytomas (four from VHL patients, nine from sporadic patients, and one from a patient with familial pheochromocytoma) for loss of heterozygosity on chromosome arm 3p by using the polymerase chain reaction and restriction fragment length polymorphisms at eight loci. Loss of heterozygosity was detected in 8 of 14 pheochromocytomas examined: in three of the four VHL\u2010associated tumors, in four of the nine sporadic tumors, and in the familial pheochromocytoma\u2010associated tumor. Deletion of the inherited wild\u2010type VHL<\/jats:italic> allele was demonstrated in both informative VHL\u2010associated pheochromocytomas, demonstrating involvement of VHL<\/jats:italic> in pheochromocytoma development. However, because VHL<\/jats:italic> mutations have not been detected in sporadic pheochromocytomas, VHL<\/jats:italic> and\/or another chromosome arm 3p gene may be involved in the etiology of these tumors. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870130303","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:10:16Z","timestamp":1172103016000},"page":"151-156","source":"Crossref","is-referenced-by-count":33,"title":["Loss of heterozygosity on the short arm of chromosome 3 in sporadic, von hippel\u2010lindau disease\u2010associated, and familial pheochromocytoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Martha A.","family":"Zeiger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berton","family":"Zbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Marston","family":"Linehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Gnarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1071","article-title":"Molecular analysis of genetic changes in the origin and development of renal cell carcinoma","volume":"51","author":"Anglard P","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","first-page":"348","article-title":"Molecular and cellular characterization of human renal cell carcinoma cell lines","volume":"52","author":"Anglard P","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380050109"},{"key":"e_1_2_1_5_1","first-page":"154","article-title":"Loading and transfer control for northern hybridization","volume":"12","author":"Correa\u2010Rotter R","year":"1992","journal-title":"Biotechniques"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.7.851"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(92)90369-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00204184"},{"key":"e_1_2_1_9_1","first-page":"312","article-title":"von Hippel\u2010Lindau disease","volume":"4","author":"Glenn GM","year":"1993","journal-title":"Prob Urol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-85"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/367375a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115186"},{"key":"e_1_2_1_13_1","first-page":"1437","article-title":"Hereditary cancer, oncogenes, and antioncogenes","volume":"45","author":"Knudson AG","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.492"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493574"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.4.287"},{"key":"e_1_2_1_17_1","first-page":"770","article-title":"Consistent association of I p loss of heterozygosity with pheochromocytomas from patients with multiple endocrine neoplasia type 2 syndromes","volume":"52","author":"Moley JF","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/363458a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0194-70"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370317"},{"key":"e_1_2_1_21_1","first-page":"894","article-title":"Loss of genes on chromosome 22 in medullary thyroid carcinoma and pheochromocytoma","volume":"78","author":"Takai S","year":"1987","journal-title":"Jpn J Cancer Res"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050416"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.14.1097"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.5.367"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870110104"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870130303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870130303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:15:36Z","timestamp":1698365736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870130303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["10.1002\/gcc.2870130303"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870130303","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}