{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:24:26Z","timestamp":1791181466863,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":3969,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twelve B\u2010cell non\u2010Hodgkin's lymphomas with <jats:italic>BCL6\/LAZ3<\/jats:italic> rearrangement selected from a series of 30 lymphomas with cyto\u2010genetically detectable 3qter abnormalities were characterized at the histological, clinical, and cytogenetic levels, including fluorescence in situ hybridization (FISH) analysis, which was performed in all cases but one. A classical t(3;14) and t(3;22) were found in three patients (25%). In the remaining cases, eleven different 3q27 abnormalities were demonstrated and characterized with the use of chromosome painting. Seven of twelve \u201cvariant\u201d rearrangements identified in our series affecting 1p32, 1p34, 3p14, 6q23, 12p13, 14q11, and 16p13 have not been reported before. Moreover, involvement of both homologs of chromosome 3 in distinct translocations was detected as an unexpected result in two cases and was confirmed via FISH in a third case. The putative bichromosomal rearrangements of the 3q27 region were evidenced by Southern analysis in one of these cases. In another case, FISH with a cosmid spanning the 3q27 breakpoint region demonstrated the involvement of <jats:italic>BCL6\/LAZ3<\/jats:italic> only in one of two t(3q27).<\/jats:p><jats:p>In our series, which was selected on cytogenetic and molecular criteria, 50% (6 of 12) of cases with <jats:italic>BCL6\/LAZ3<\/jats:italic> rearrangement were diagnosed as diffuse, large B\u2010cell lymphomas (DLCL). Another 33% (4 of 12) of cases were diagnosed as follicular center lymphomas (FL), with t(14;18)\/BCL2 rearrangement in all but one case. Furthermore, in three follicular lymphoma cases in which multiple samples were analyzed, the disease showed no evidence of histological progression during a follow\u2010up period of 3\u201014 years. The present data show that rearrangement of BCL6 is not restricted to high\u2010grade malignancies as was previously suggested but can also occur in low\u2010grade lymphomas. In addition, the appearance of <jats:italic>BCL6\/LAZ3<\/jats:italic> rearrangement in follicular lymphomas is not related to disease progression.<\/jats:p>","DOI":"10.1002\/gcc.2870140102","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:43:24Z","timestamp":1172105004000},"page":"1-7","source":"Crossref","is-referenced-by-count":38,"title":["Fluorescence in situ hybridization identifies new chromosomal changes involving 3q27 in non\u2010Hodgkin's lymphomas with <i>BCL6<\/i>\/<i>LAZ3<\/i> rearrangement"],"prefix":"10.1002","volume":"14","author":[{"given":"Iwona","family":"Wlodarska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mecucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Stul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne","family":"Michaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Maria","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Jacques","family":"Cassiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"De Wolf\u2010Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"van den Berghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.11.5262"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.10.2527.2527"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","article-title":"LAZ3 rearrangements in non\u2010Hodgkin's lymphoma correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients","volume":"83","author":"Bastard C","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870080303"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1182\/blood.V84.2.397.397","article-title":"Rearrangements of the BCL\u20106 gene in acquired immunodeficiency syndrome\u2010associated non\u2010Hodgkin's lymphoma association with diffuse large\u2010cell subtype","volume":"84","author":"Gaidano G","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.5.1361.1361"},{"key":"e_1_2_1_8_1","first-page":"1971","article-title":"Translocation t(3;22)(q27;q11) in non Hodgkin's malignant lymphoma: Chromosome painting and molecular studies","volume":"7","author":"Hebert J","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_1_9_1","volume-title":"Guidelines for Cancer 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