{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:14:43Z","timestamp":1785842083690,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":3939,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endometrial and ovarian carcinomas are common among women belonging to hereditary nonpolyposis colorectal carcinoma (HNPCC) families; tumors developing in them are characterized by genetic instability due to an inherited dysfunction of the DNA\u2010mismatch\u2010repair system. To clarify the role of similar genetic factors in sporadic forms of gynecological tumors, we examined 77 endometrial and 68 ovarian carcinomas for replication error (RER) at five microsatellite loci. RER\u2010positive phenotypes at two or more microsatellite loci were observed in 18 of the endometrial carcinomas, but in only two of the ovarian carcinomas. Among the patients with endometrial carcinomas, the frequency of RER tended to be higher in those under age 50 than in those over age 60. Furthermore, RER was significantly more frequent in poorly differentiated than in well\u2010differentiated tumors (<jats:italic>P<\/jats:italic> = 0.008, Fisher's exact test). These data suggest that genetic factors characterized by RER are likely to play an important role in some endometrial carcinomas, particularly those of early onset and\/or of the poorly differentiated type.<\/jats:p>","DOI":"10.1002\/gcc.2870140207","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:42:51Z","timestamp":1172104971000},"page":"128-132","source":"Crossref","is-referenced-by-count":77,"title":["Microsatellite instability in endometrial carcinomas: Frequent replication errors in tumors of early onset and\/or of poorly differentiated type"],"prefix":"10.1002","volume":"14","author":[{"given":"Kanji","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Sagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Koi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8484121"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-700"},{"key":"e_1_2_1_4_1","first-page":"1163","article-title":"Microsatellite instability in endometrial carcinoma","volume":"9","author":"Burks RT","year":"1994","journal-title":"Oncogene"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.16.1216"},{"key":"e_1_2_1_6_1","first-page":"5308","article-title":"K\u2010ras activation in premalignant and malignant epithelial lesions of the human uterus","volume":"51","author":"Enomoto T","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_1","first-page":"1883","article-title":"Alterations of the p53 tumor suppressor gene and its association with activation of c\u2010k\u2010ras protooncogene in premalignant and malignant lesions of the human uterine endometrium","volume":"53","author":"Enomoto T","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90027-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694supp-246"},{"key":"e_1_2_1_10_1","first-page":"5087","article-title":"Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer","volume":"53","author":"Han H\u2010J","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530617"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91663-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/363558a0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.2.131"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050113"},{"key":"e_1_2_1_16_1","first-page":"1622","article-title":"Overexpression and mutation of p53 endometrial carcinoma","volume":"52","author":"Kohler MF","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_1","first-page":"5849","article-title":"Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history","volume":"53","author":"Lothe RA","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1966.03870080050009"},{"key":"e_1_2_1_19_1","first-page":"337","article-title":"Hereditary colorectal cancer","volume":"18","author":"Lynch HT","year":"1991","journal-title":"Semin Oncol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90368-M"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(75)90041-4"},{"key":"e_1_2_1_22_1","first-page":"5632","article-title":"Allelic loss on chromosome 17p and p53 mutations in human endometrial carcinoma of the uterus","volume":"51","author":"Okamoto A","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.20.9495"},{"key":"e_1_2_1_24_1","unstructured":"RiceLAG HankyBF MillerBA HartmanAM EdwardsBK(1991) Cancer Statistics Review 1973\u20131988.National Cancer Institute NIH Pub (Bethesda) No. 91\u20102789."},{"key":"e_1_2_1_25_1","first-page":"5100","article-title":"Genetic instability of microsatellites in endometrial carcinoma","volume":"53","author":"Risinger JI","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_26_1","first-page":"1906","article-title":"Mutation of Ki\u2010ras protooncogene in human endometrial hyperplasia and carcinoma","volume":"53","author":"Sasaki H","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_27_1","first-page":"7184","article-title":"Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer","volume":"50","author":"Sato T","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8484122"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930201)71:3<677::AID-CNCR2820710305>3.0.CO;2-#"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/359794a0"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-152"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870140207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870140207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:26:30Z","timestamp":1698362790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870140207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1002\/gcc.2870140207"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870140207","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}