{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:51Z","timestamp":1792030071648,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["RCU_H_64_016_30"],"award-info":[{"award-number":["RCU_H_64_016_30"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Most meningiomas are dural\u2010based extra\u2010axial tumors in close contact with the brain. Expression of genes and proteins at the tumor\u2010brain interface in brain\u2010invasive meningioma is basically unknown. Using the NanoString pan\u2010cancer panel, differential expression of genes in the invasive edge versus main tumor body was determined in 12 invasive meningiomas (comprising the discovery cohort), and 6 candidate genes: <jats:italic>DTX1<\/jats:italic>, <jats:italic>RASGRF1<\/jats:italic>, <jats:italic>GRIN1<\/jats:italic>, <jats:italic>TNR<\/jats:italic>, <jats:italic>IL6<\/jats:italic>, and <jats:italic>NR4A1<\/jats:italic>, were identified. By immunohistochemistry, DTX1 and RASGRF1 expression correlated with gene expression, and were studied in an expanded cohort of 21 invasive and 15 noninvasive meningiomas, together with Ki\u201067. Significantly higher expression of DTX1, RASGFR1, and Ki\u201067 was found in the invasive edge compared with the main tumor body. Increased expression of RASGRF1 and Ki\u201067 was more clearly associated with brain invasion. The situation with DTX1 was less definitive since increased expression was observed in meningiomas both at the invasive edge and when in close contact with brain but without invasion. Pathway analyses identified significant links between <jats:italic>DTX1<\/jats:italic> and <jats:italic>RASGRF1<\/jats:italic> and key biological processes, including cell\u2013cell adhesion, and signaling pathways including Notch, RAS, MAPK, and Rho. Higher expression of DTX1, RASGRF1, and Ki\u201067 in the brain\u2010invasive area of meningiomas suggests that these proteins play a role in the process of brain invasion.<\/jats:p>","DOI":"10.1002\/gcc.70007","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T13:49:05Z","timestamp":1731505745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential Expression of Proteins and Genes at the Tumor\u2010Brain Interface in Invasive Meningioma"],"prefix":"10.1002","volume":"63","author":[{"given":"Kornwika","family":"Senglek","sequence":"first","affiliation":[{"name":"Doctor of Philosophy Program of Medical Sciences, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Pathology and Forensic Medicine Department Chulabhorn Hospital, Chulabhorn Royal Academy  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinachote","family":"Teerapakpinyo","sequence":"additional","affiliation":[{"name":"Chulalongkorn GenePRO Center, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nutchawan","family":"Jittapiromsak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pakrit","family":"Jittapiromsak","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irin","family":"Lertparinyaphorn","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-5566","authenticated-orcid":false,"given":"Paul Scott","family":"Thorner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-337X","authenticated-orcid":false,"given":"Shanop","family":"Shuangshoti","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Chulalongkorn GenePRO Center, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/cns-2021-0003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2002049"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.168"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.8.JNS221290"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2023.2193333"},{"key":"e_1_2_11_8_1","first-page":"284","volume-title":"WHO Classification of Tumours Editorial Board. 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