{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:54:29Z","timestamp":1761062069105,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K06919"],"award-info":[{"award-number":["JP21K06919"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>MN1<\/jats:italic> fusion is emerging as oncogenic in soft\u2010tissue tumors. Here, we provided detailed clinicopathological documentation of a tumor with <jats:italic>MN1<\/jats:italic>::<jats:italic>TAF3<\/jats:italic> fusion. The tumor developed on the face of an 8\u2010year\u2010old boy and did not recur or metastasize for 5\u2009years after surgery without adjuvant therapy. Histologically, the tumor predominantly comprised sheets and nests of atypical, mildly pleomorphic epithelioid cells. Mallory body\u2010like eosinophilic cytoplasmic inclusions, small round cells, and fascicles of spindle cells were focally observed. Mitotic activity was high, and focal necrosis was present. Immunohistochemically, the tumor was positive for cytokeratin AE1\/AE3 in the epithelioid cell component but otherwise showed nonspecific phenotypes. Targeted RNA sequencing identified an in\u2010frame <jats:italic>MN1<\/jats:italic> (exon 1)::<jats:italic>TAF3<\/jats:italic> (exon 3) fusion transcript. We validated the transcript with reverse transcription\u2010polymerase chain reaction, Sanger sequencing, and <jats:italic>MN1<\/jats:italic> break\u2010apart fluorescence in\u00a0situ hybridization. <jats:italic>MN1<\/jats:italic>::<jats:italic>TAF3<\/jats:italic> was previously listed without details in a large\u2010scale sequencing study involving a pediatric round cell sarcoma in the orbit, raising the possibility that these tumors might form a coherent group.<\/jats:p>","DOI":"10.1002\/gcc.70009","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T13:25:01Z","timestamp":1731677101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric Mesenchymal Tumor With <i>MN1<\/i>::<i>TAF3<\/i> Fusion"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8124-9785","authenticated-orcid":false,"given":"Chikako","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Laboratory Medicine National Defense Medical College Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanaka","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-7883","authenticated-orcid":false,"given":"Taisuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitose","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Center Hospital  Tokyo Japan"},{"name":"Rare Cancer Center, National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3373-0099","authenticated-orcid":false,"given":"Akihiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"},{"name":"Rare Cancer Center, National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","first-page":"1521","article-title":"Cloning and Characterization of MN1, a Gene From Chromosome 22q11, Which Is Disrupted by a Balanced Translocation in a Meningioma","volume":"10","author":"Lekanne Deprez R. H.","year":"1995","journal-title":"Oncogene"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.04.014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-014845"},{"volume-title":"WHO Classification of the Central Nervous System Tumours","year":"2021","author":"Brat D. 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