{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:04:59Z","timestamp":1787785499162,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KU1002A\u2010J"],"award-info":[{"award-number":["01KU1002A\u2010J"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["036166B"],"award-info":[{"award-number":["036166B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KU1505E"],"award-info":[{"award-number":["01KU1505E"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mature aggressive B\u2010cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large B\u2010cell lymphoma (DLBCL), show variations in microRNA (miRNA) expression. The entity of High\u2010grade B\u2010cell lymphoma with 11q aberration (HGBCL\u201011q) shares several biological features with both BL and DLBCL but data on its miRNA expression profile are yet scarce. Hence, this study aims to analyze the potential differences in miRNA expression of HGBCL\u201011q compared to BL and DLBCL. We evaluated the expression profiles of 2083 miRNAs in 25 HGCBL\u201011q, 7 BL, 131 DLBCL, and tonsils using the HTG EdgeSeq miRNA whole transcriptome assay. Uniform manifold approximation and projection (UMAP) and differential gene expression analyses based on DESeq2 were carried out. UMAP analysis of miRNA expression did not reveal distinct groups among the studied lymphomas. However, differential gene expression investigations detected sets of overexpressed miRNAs in HGBCL\u201011q when compared to BL (miR\u20109\u20103p, miR\u20109\u20105p, miR\u20103919, miR\u2010129\u20101\u20103p, miR\u2010129\u20102\u20103p, miR\u2010331\u20103p, miR\u2010196b\u20105p, and miR\u201028\u20105p) and DLBCL (miR\u20103919, miR\u20101290, miR\u20104538, and miR\u20104791), respectively. Notably, miR\u20103919 showed heterogeneous but significantly higher expression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value &lt;\u20090.001) in HGBCL\u201011q than in both, BL and DLBCL. We identified a group of differentially expressed miRNAs between HGBCL\u201011q vs. BL and DLBCL, with miR\u20103919 as the most commonly and recurrently overexpressed miRNA in HGBCL\u201011q.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70021","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T04:43:56Z","timestamp":1737607436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>MicroRNA<\/scp>\n                    Expression in High\u2010Grade B\u2010Cell Lymphoma With 11q Aberration"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-4437","authenticated-orcid":false,"given":"Gioia","family":"Di Stefano","sequence":"first","affiliation":[{"name":"Histopathology and Molecular Diagnostics Careggi University Hospital  Florence Italy"},{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Fischer","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-9291","authenticated-orcid":false,"given":"Emil","family":"Chteinberg","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Bens","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Wagener","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Abramov","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Adam","sequence":"additional","affiliation":[{"name":"Pathologie Ingolstadt and Institute of Pathology, TUM School of Medicine and Health Technical University Munich (TUM)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan H.","family":"Bernhart","sequence":"additional","affiliation":[{"name":"Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Haematology and Clinical Immunology, Medical Faculty Heinrich\u2010Heine\u2010University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology University Hospital Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Del\u2010Val","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics Ulm University and Ulm University Medical Center  Ulm Germany"},{"name":"Department of Computer Science and Artificial Intelligence, University of Granada Andalusian Research Institute in Data Science and Computational Intelligence  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria Ibs. Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Fr\u00fchwald","sequence":"additional","affiliation":[{"name":"Pediatrics and Adolescent Medicine, Swabian Children's Cancer Center University Hospital Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Guazzo","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica I.","family":"Hoell","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology Martin Luther University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hummel","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t Zu Berlin &amp; Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart  Germany"},{"name":"Dr. Margarete Fischer\u2010Bosch Institute of Clinical Pharmacology, Stuttgart, and University of T\u00fcbingen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"Section Haematopathology and Lymph Node Registry, Department of Pathology Christian\u2010Albrechts\u2010University Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Krugmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie Klinikum Bayreuth  Bayreuth 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