{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:52:43Z","timestamp":1776865963009,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Approximately 10% of Ph\u2010Like patients have <jats:italic>ABL<\/jats:italic> class gene fusions, which include the <jats:italic>FIP1L1::PDGFRA<\/jats:italic> rearrangement. We report a case of a pediatric patient with Ph\u2010like B\u2010lymphoblastic leukemia (B\u2010LL) with a <jats:italic>FIP1L1::PDGFRA<\/jats:italic> fusion and their treatment course using a combination of chemotherapy and targeted therapy with imatinib. A 10\u2010year\u2010old female presented with lethargy, palpitations, and fevers. She had pancytopenia, no eosinophilia, and flow cytometry consistent with B\u2010LL. FISH identified a <jats:italic>CHIC2<\/jats:italic> deletion, suggestive of <jats:italic>FIP1L1::PDGFRA<\/jats:italic> fusion, confirmed on next\u2010generation RNA sequencing. The patient commenced targeted therapy with imatinib, which she continued until completion of standard chemotherapy per COG AALL1732. She remains in remission 6\u2009months post\u2010completion of therapy. B\u2010ALL with a <jats:italic>FIP1L1::PDGFRA<\/jats:italic> fusion is extremely rare, particularly in pediatrics. <jats:italic>FIP1L1::PDGFRA<\/jats:italic> rearrangements can be difficult to detect on routine testing and may not always be seen in association with eosinophilia. Identification of <jats:italic>FIP1L1::PDGFRA<\/jats:italic> rearrangements is important as they enable treatment with a tyrosine kinase inhibitor, which has significantly improved the overall prognosis for <jats:italic>PDGFRA<\/jats:italic>\u2010rearranged neoplasms. Prospective studies assessing imatinib dosage, duration, and long\u2010term safety are warranted in this cohort.<\/jats:p>","DOI":"10.1002\/gcc.70037","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T11:07:43Z","timestamp":1741604863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>FIP1L1::PDGFRA<\/i> Fusion in a Pediatric Patient Presenting With B\u2010Cell Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-9955","authenticated-orcid":false,"given":"Jenna","family":"Nunn","sequence":"first","affiliation":[{"name":"Children's Health Queensland Hospital &amp; Health Service  Brisbane Australia"},{"name":"The University of Queensland  Brisbane Australia"},{"name":"Griffith University  Gold Coast Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bronwyn","family":"Williams","sequence":"additional","affiliation":[{"name":"Children's Health Queensland Hospital &amp; Health Service  Brisbane Australia"},{"name":"Pathology Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Deambrosis","sequence":"additional","affiliation":[{"name":"Children's Health Queensland Hospital &amp; Health Service  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25617"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2023.05.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22655"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2010.08394.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31827e6386"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12416"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2017.07.007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/mph.0000000000001446"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102018\u2010227653"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000486"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1059527"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318290c24f"},{"key":"e_1_2_11_14_1","volume-title":"WHO Classification of Tumours: Myeloid\/Lymphoid Neiplasms With Eosinophilia and Tyorsine Kinase Gene Fusions","author":"WHO","year":"2024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.129"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25199"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1710"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000193467.06938.77"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2022.03.008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000182"},{"key":"e_1_2_11_21_1","unstructured":"NCI \u201cImatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Clinical Trials) \u201d(2024)."}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:22:01Z","timestamp":1741771321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/gcc.70037"],"URL":"https:\/\/doi.org\/10.1002\/gcc.70037","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2025-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70037"}}