{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:06:53Z","timestamp":1791252413781,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>According to the 5th edition of the WHO Classification of Soft Tissue and Bone Tumors, the diagnosis of synovial sarcoma relies on morphology, immunohistochemistry, and the detection of a specific fusion involving the <jats:italic>SS18<\/jats:italic> gene with a member of the <jats:italic>SSX<\/jats:italic> gene family. However, few cases of synovial sarcoma that do not harbor such molecular alterations have been recently reported. We present the case of a patient with a diffuse pleural mass and pleural effusion that showed in a core needle biopsy a spindle cell neoplasia morphologically suggestive of synovial sarcoma. An <jats:italic>SS18<\/jats:italic> break\u2010apart FISH was performed with a negative result. Afterwards, an <jats:italic>EWSR1::SSX1<\/jats:italic> fusion was detected by next\u2010generation sequencing. There is scarce literature on non\u2010SS18 fusion\u2010driven synovial sarcomas, and no study has evaluated whether these novel molecular alterations have a relevant clinical impact on patients beyond the diagnostic value.<\/jats:p>","DOI":"10.1002\/gcc.70048","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T13:12:50Z","timestamp":1744290770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>EWSR1::SSX1<\/scp> Fusion\u2010Driven Synovial Sarcoma: A Case Presentation and Review of the Literature"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-9697","authenticated-orcid":false,"given":"Jesus","family":"Vega\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Department of Pathology, Hospital Universitario Cl\u00ednico San Carlos Health Research Institute \u201cSan Carlos\u201d (IdISCC), Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio Cort\u00e9s","family":"Toro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Cl\u00ednico San Carlos Health Research Institute \u201cSan Carlos\u201d (IdISCC), Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esthefan\u00eda Latorre","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital General Universitario Nuestra Se\u00f1ora del Prado, Talavera de la Reina  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8961-9787","authenticated-orcid":false,"given":"Gloria","family":"Marquina","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hospital Clinico San Carlos School of Medicine, UCM, IdissC, EURACAN Referral Centre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat de la Torre","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Cl\u00ednico San Carlos Health Research Institute \u201cSan Carlos\u201d (IdISCC), Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda Colino","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Cl\u00ednico San Carlos Health Research Institute \u201cSan Carlos\u201d (IdISCC), Universidad Complutense de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes Bergillos","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Cl\u00ednico San Carlos Health Research Institute \u201cSan Carlos\u201d (IdISCC), Universidad Complutense de Madrid  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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1175","volume-title":"Enzinger & Weiss's Soft Tissue Tumors","author":"Goldblum R. 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