{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T02:13:32Z","timestamp":1778033612895,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report a uterine myxoid mesenchymal tumor with a novel <jats:italic>SS18::VEZF1<\/jats:italic> gene fusion. The current lesion was identified in a 53\u2010year\u2010old woman who presented with symptomatic \u201cfibroids\u201d showing accelerated growth and heterogeneous morphology on radiologic assessment. Microscopic examination revealed a well\u2010demarcated neoplasm, and the tumor exhibited alternating hypocellular\/hyalinized and hypercellular areas, composed of a monomorphic proliferation of spindle, ovoid, and epithelioid cells arranged in sheets. These cells were embedded within either a hyalinized collagenous stroma or abundant myxoid stroma. Tumor cells were frequently located around blood vessels and exhibited amphophilic or eosinophilic cytoplasm and elongated or ovoid\u2010shaped nuclei with coarsely clumped chromatin. No mitoses, pleomorphism, or necrosis was identified. Immunohistochemically, the tumor was positive for CD10, CD34, TLE1, estrogen, and progesterone receptors. It was negative for h\u2010caldesmon, desmin, smooth muscle actin, smoothelin, myosin, cyclin D1, S100, ALK, EMA, panTRK, and SS18\u2010SSX. Targeted RNA sequencing revealed an <jats:italic>SS18::VEZF1<\/jats:italic> gene fusion (breakpoint: <jats:italic>exon 9<\/jats:italic>\u2013<jats:italic>exon 2<\/jats:italic>), which was confirmed by FISH (<jats:italic>SS18<\/jats:italic>). In conclusion, RNA sequencing was useful in identifying the fusion event, thereby excluding potential mimics with uncommon morphology or ambiguous immunophenotype.<\/jats:p>","DOI":"10.1002\/gcc.70079","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T05:13:21Z","timestamp":1756444401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uterine Myxoid Mesenchymal Tumor With a Novel <i>SS18::VEZF1<\/i> Gene Fusion, Lacking Worrisome Histological Features"],"prefix":"10.1002","volume":"64","author":[{"given":"Isidro","family":"Machado","sequence":"first","affiliation":[{"name":"Pathology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"},{"name":"Patologika Laboratory Hospital QuironSalud  Valencia Spain"},{"name":"Pathology Department University of Valencia  Valencia Spain"},{"name":"CIBERONC  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyes","family":"Claramunt","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pathology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Aliaga","sequence":"additional","affiliation":[{"name":"Pathology Department Instituto Valenciano de Oncolog\u00eda  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Garrig\u00f3s","sequence":"additional","affiliation":[{"name":"Gynecology Department Instituto Valenciano de Oncolog\u00eda  Valencia 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