{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:33:03Z","timestamp":1791844383319,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>With the increasing use of next\u2010generation sequencing, the classification of heretofore unclassified neoplasms is evolving rapidly. Specifically, gene fusions have emerged as context\u2010specific defining genetic markers for an increasing number of entities, mostly of soft tissue, bone, and salivary gland origin. We describe four myoepithelial\u2010like neoplasms of salivary (two) and pulmonary (two) origin, carrying recurrent <jats:italic>NFATC2<\/jats:italic> fusions involving <jats:italic>NUTM2B<\/jats:italic> (three) and <jats:italic>NUTM2A<\/jats:italic> (one) as fusion partners. Patients were two females and two males aged 24\u201367\u2009years (median, 33). The tumor size ranged from 1 to 4.5\u2009cm. Treatment was surgery without (three) or with (one) adjuvant radiochemotherapy. No metastases or other primary tumors were found at the time of diagnosis. Three patients with follow\u2010up (two with salivary, one with pulmonary tumor) were disease\u2010free at 9, 11, and 31\u2009months. Original diagnoses were \u201cunclassified neoplasm\u201d with consideration of adamantinoma\u2010like Ewing sarcoma and myoepithelial neoplasm. Histology revealed infiltrating monotonous epithelioid to basaloid cells arranged into lobular aggregates, nests, and cords within variably sclerosed stroma containing extensive basement membrane\u2010like hyaline material. Frankly malignant features (malignant cytology, high mitotic activity, necrosis, perineural or lymphovascular invasion) were absent. IHC showed coexpression of low and high molecular weight keratins (AE1\/AE3 and CK5\/6; 4\/4), EMA (2\/2), and CD99 (2\/2). Negative markers included p63 (0\/4), NUT (0\/4), S100 (0\/4), SOX10 (0\/4), p40 (0\/2), and SMA (0\/2). This study introduces a novel salivary and lung tumor entity driven by <jats:italic>NFATC2::NUTM2A\/B<\/jats:italic> fusions and displaying myoepithelial\u2010like morphology but imperfect myoepithelial immunophenotype. Report of more cases should shed light on the biological properties and appropriate therapeutic strategies of this novel neoplasm.<\/jats:p>","DOI":"10.1002\/gcc.70083","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T07:06:15Z","timestamp":1757747175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>NFATC2::NUTM2A\/B<\/i> Fusions Characterize a Novel Indolent Myoepithelial\u2010Like Neoplasm of the Lungs and Salivary Glands"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-8161","authenticated-orcid":false,"given":"Abbas","family":"Agaimy","sequence":"first","affiliation":[{"name":"Institute of Pathology, Erlangen University Hospital Friedrich Alexander University of Erlangen\u2010Nuremberg  Erlangen Germany"},{"name":"Comprehensive Cancer Center European Metropolitan Area Erlangen\u2010Nuremberg (CCC ER\u2010EMN)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine K.","family":"Dermawan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Pathology and Laboratory Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabete","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Pathology ULS S\u00e3o Jo\u00e3o  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Meidenbauer","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center European Metropolitan Area Erlangen\u2010Nuremberg (CCC ER\u2010EMN)  Erlangen Germany"},{"name":"Department of Internal Medicine 5\u2010Hematology and Oncology, Erlangen University Hospital Friedrich Alexander University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"Dimmler","sequence":"additional","affiliation":[{"name":"Institut und Praxis f\u00fcr Pathologie ViDia Christliche Kliniken  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Stoehr","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Erlangen University Hospital Friedrich Alexander University of Erlangen\u2010Nuremberg  Erlangen Germany"},{"name":"Comprehensive Cancer Center European Metropolitan Area Erlangen\u2010Nuremberg (CCC ER\u2010EMN)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8205","authenticated-orcid":false,"given":"Cristina R.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000554"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22320"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.01.012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000629"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01401-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000286"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001584"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14314"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22984"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.03.020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.05.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0542-z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969241228294"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2023.07.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15380"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100729"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22857"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:51:54Z","timestamp":1758869514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.70083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/gcc.70083"],"URL":"https:\/\/doi.org\/10.1002\/gcc.70083","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70083"}}