{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:56:20Z","timestamp":1785772580895,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Many cutaneous adnexal tumors share molecular alterations with other homologous neoplasms occurring in salivary glands. Polymorphous adenocarcinoma (PAC) is a rare salivary gland tumor, usually associated with alterations in the\n                    <jats:italic>PRKD<\/jats:italic>\n                    gene family. In this report, we describe a primary cutaneous sweat gland adenocarcinoma of the scalp occurring in a 65\u2010year\u2010old female. Morphological features of the carcinoma were reminiscent of salivary gland PAC. Tumor cells were CK7+ S100+ SOX10+ p63 focally positive and p40\u2010. Whole\u2010transcriptome sequencing of the lesion showed the presence of an in\u2010frame\n                    <jats:italic>ATL2::PRKD3<\/jats:italic>\n                    fusion.\n                    <jats:italic>PRKD1<\/jats:italic>\n                    ,\n                    <jats:italic>2<\/jats:italic>\n                    or\n                    <jats:italic>3<\/jats:italic>\n                    fusions are characteristic of the cribriform subtype of PAC (cribriform adenocarcinoma of salivary gland, CASG). No past history of salivary gland tumor nor existing salivary gland tumor was retrieved in the patient. After complete excision of the tumor, the patient has been in complete remission for 17\u2009months. This case suggests that a subset of adnexal adenocarcinomas of not otherwise specified type (NOS) may carry\n                    <jats:italic>PRKD<\/jats:italic>\n                    alteration and may constitute the cutaneous counterpart of salivary gland PAC\/CASG. This finding argues in favor of a more systematic molecular exploration of adnexal adenocarcinomas NOS for better classification and prognosis.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70093","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T05:41:46Z","timestamp":1763012506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Sweat Gland Adenocarcinoma of the Skin With\n                    <i>ATL2::PRKD3<\/i>\n                    Fusion: A Potential Cutaneous Analog of Cribriform Adenocarcinoma of the Salivary Glands?"],"prefix":"10.1002","volume":"64","author":[{"given":"Ana\u00efs","family":"Brunet","sequence":"first","affiliation":[{"name":"Pathology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barouyr","family":"Baroudjian","sequence":"additional","affiliation":[{"name":"Department of Dermatology AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxence","family":"Mancini","sequence":"additional","affiliation":[{"name":"Tumor Genomics and Pharmacology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1342  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan\u00e9lie","family":"Jouenne","sequence":"additional","affiliation":[{"name":"Tumor Genomics and Pharmacology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1342  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Louveau","sequence":"additional","affiliation":[{"name":"Tumor Genomics and Pharmacology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1342  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Moulonguet","sequence":"additional","affiliation":[{"name":"Department of Dermatology AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Osio","sequence":"additional","affiliation":[{"name":"Pathology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Mourah","sequence":"additional","affiliation":[{"name":"Tumor Genomics and Pharmacology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1342  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"Pathology Department AP\u2010HP H\u00f4pital Saint\u2010Louis  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1342  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14610"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030476"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896918770010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000734"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.6359"},{"key":"e_1_2_8_7_1","volume-title":"Head and Neck Tumours [Internet]. WHO Classification of Tumours Series","author":"WHO Classification of Tumours Editorial Board","year":"2023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22195"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001431"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010019\u20100351\u20104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174156"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2023.100305"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2021.03.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08280"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.09.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14081559"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2020.4049"},{"key":"e_1_2_8_18_1","volume-title":"Skin Tumours [Internet; Beta Version Ahead of Print]. WHO Classification of Tumours Series","author":"WHO Classification of Tumours Editorial Board","year":"2023"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485371"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000073"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13799"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:35:41Z","timestamp":1764225341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/gcc.70093"],"URL":"https:\/\/doi.org\/10.1002\/gcc.70093","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70093"}}