{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:24:11Z","timestamp":1785601451831,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a\n                    <jats:italic>GLI1<\/jats:italic>\n                    \u2010altered mesenchymal tumor of the duodenum with a novel\n                    <jats:italic>TNFAIP3::GLI1<\/jats:italic>\n                    gene fusion, deceptive morphology, and late recurrence. The patient was a 72\u2010year\u2010old female who was found to have a polypoid 3.7\u2009cm duodenal mass which, based on epithelioid morphology and focal immunoreactivity for cytokeratin, was diagnosed as invasive adenocarcinoma following review by an academic consultant. Sixty\u2010seven months later, the patient presented with multiple liver nodules representing metastatic disease. RNA sequencing demonstrated a novel\n                    <jats:italic>TNFAIP3::GLI1<\/jats:italic>\n                    gene fusion in the liver lesion, which had higher mitotic activity but showed similar pure epithelioid morphology and immunophenotype as the original small bowel lesion. In addition to expanding the spectrum of\n                    <jats:italic>GLI1<\/jats:italic>\n                    \u2010associated gene fusions, this case highlights the potential for misdiagnosis of epithelioid\n                    <jats:italic>GLI1<\/jats:italic>\n                    \u2010altered mesenchymal tumors as adenocarcinoma (particularly given the variable immunoreactivity for cytokeratin), and the need for long\u2010term follow up of these typically slowly growing neoplasms.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70104","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:07:23Z","timestamp":1767006443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>\n                      <i>GLI1<\/i>\n                    <\/scp>\n                    \u2010Altered Mesenchymal Tumor of the Duodenum With a Novel\n                    <i>TNFAIP3::GLI1<\/i>\n                    Gene Fusion: Report of a Diagnostically Challenging Case Associated With Late Metastasis"],"prefix":"10.1002","volume":"64","author":[{"given":"Pedram","family":"Argani","sequence":"first","affiliation":[{"name":"Department of Pathology and Oncology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan J.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Washington  Seattle Washington USA"},{"name":"ARUP Laboratories  Salt Lake City Utah 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