{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:55:46Z","timestamp":1787316946604,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>TRAF7<\/jats:italic>\n                    mutations are a rare occurrence in human cancer and have recently been described in a group of mesenchymal tumors with varying clinical course. Herein, we expand the spectrum of\n                    <jats:italic>TRAF7<\/jats:italic>\n                    \u2010mutated fibromyxoid spindle cell tumors by reporting the first case to arise in bone. A 60\u2010year\u2010old woman presented with right knee pain and was incidentally found to have a left distal femur lesion, which was first detected 20\u2009years prior when it was favored to be benign. Recent imaging studies revealed significant interval growth with focal cortical destruction and soft tissue extension. Histologic examination showed a bland spindle cell neoplasm with fibrous to myxoid stroma. Rare mitotic figures were present; necrosis and marked cytologic atypia were absent. Immunohistochemical work\u2010up showed that the spindle cells only demonstrated focal cytoplasmic staining with L1CAM, and whole exome sequencing identified a\n                    <jats:italic>TRAF7<\/jats:italic>\n                    p.Y563C missense mutation. The tumor was resected, and the patient is recovering well at 2\u2009months with no evidence of local recurrence or distant disease. This report is the first known case of a\n                    <jats:italic>TRAF7<\/jats:italic>\n                    \u2010mutated fibromyxoid spindle cell tumor of bone with the longest clinical follow\u2010up reported to date.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70118","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:35:33Z","timestamp":1773236133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>TRAF7<\/i>\n                    <\/scp>\n                    \u2010Mutated Fibromyxoid Spindle Cell Tumor of Bone: An Osseous Case Expanding the Spectrum of\n                    <scp>\n                      <i>TRAF7<\/i>\n                    <\/scp>\n                    \u2010Mutated Tumors With Over 20\u2009Years Clinical Follow\u2010Up"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-3282","authenticated-orcid":false,"given":"Laura M.","family":"Warmke","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Toklu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer M.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-492X","authenticated-orcid":false,"given":"L. Daniel","family":"Wurtz","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Ladd","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin J.","family":"Conway","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02111"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1093-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010225"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24854"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.02.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.153"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13726"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3520"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0330-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-9-r96"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-16004-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0127-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.06.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0792-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25676"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001997"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.70092"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.149"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.09.036"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13109"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now025"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01401-4"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/gcc.70118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:43:17Z","timestamp":1777804997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.70118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/gcc.70118"],"URL":"https:\/\/doi.org\/10.1002\/gcc.70118","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2026-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70118"}}