{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:28:13Z","timestamp":1791412093541,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>ETV6<\/jats:italic>\n                    ::\n                    <jats:italic>ACSL6<\/jats:italic>\n                    fusion gene resulting from the reciprocal translocation t(5;12)(q31;p13) is a rare but recurrent aberration in patients with myeloid neoplasms of variable phenotype. Cytogenetically, there is a high resemblance to the t(5;12)(q32;p13) leading to the imatinib\u2010sensitive\n                    <jats:italic>ETV6<\/jats:italic>\n                    ::\n                    <jats:italic>PDGFRB<\/jats:italic>\n                    fusion gene. Therefore, distinction of these entities by complementary molecular genetic tools is crucial, as patients with\n                    <jats:italic>ETV6<\/jats:italic>\n                    ::\n                    <jats:italic>ACSL6<\/jats:italic>\n                    fusion have a poor prognosis with no response to imatinib or alternative tyrosine kinase inhibitors (TKI). We performed a comprehensive analysis of 7 patients harboring the\n                    <jats:italic>ETV6<\/jats:italic>\n                    ::\n                    <jats:italic>ACSL6<\/jats:italic>\n                    fusion, using clinical and morphological characteristics, chromosome banding analysis (CBA), fluorescence in\u00a0situ hybridization (FISH) and molecular genetic analyses including whole transcriptome sequencing (WTS) as well as whole genome sequencing (WGS). Patients presented with an increase in leukocytes, eosinophils and basophils. The phenotype was a chronic myeloid neoplasm in 6 patients and acute myeloid leukemia (AML) in 1 patient. The t(5;12)(q31;p13) was the sole abnormality in four out of seven cases, and the remaining 3 cases showed a complex karyotype with \u2265\u20093 aberrations comprising a\n                    <jats:italic>TP53<\/jats:italic>\n                    deletion. No recurrent molecular mutations or other fusions were identified, suggesting that\n                    <jats:italic>ETV6<\/jats:italic>\n                    ::\n                    <jats:italic>ACSL6<\/jats:italic>\n                    functions as a driver event in the pathogenesis of all cases. Five out of seven patients received intensive chemotherapy, including allogeneic hematopoietic transplantation (alloHCT) in 4 patients. The median overall survival of 5 patients with available follow\u2010up was 11\u2009months. We conclude that the reciprocal translocation t(5;12)(q32;p13) requires a careful and step\u2010wise diagnostic work\u2010up to differentiate between an underlying\n                    <jats:italic>ETV6::PDGFRB<\/jats:italic>\n                    fusion gene with associated excellent prognosis on imatinib and an\n                    <jats:italic>ETV6::ACSL6<\/jats:italic>\n                    fusion gene, for which the prognosis is poor and alloHCT appears to be a promising therapeutic option.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70119","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:38:42Z","timestamp":1774420722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Myeloid Neoplasms With a t(5;12)(q31;p13) and an Associated\n                    <i>ETV6<\/i>\n                    ::\n                    <i>ACSL6<\/i>\n                    Gene Fusion Are Diagnostically Challenging and Have a Poor Prognosis"],"prefix":"10.1002","volume":"65","author":[{"given":"Bettina","family":"Balk","sequence":"first","affiliation":[{"name":"MLL Munich Leukemia Laboratory  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marietta","family":"Truger","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencke","family":"Walter","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schauwvlieghe","sequence":"additional","affiliation":[{"name":"Department of Hematology AZ St\u2010Jan Brugge Hospital  Bruges Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"L\u00fcbke","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, University Hospital Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6333-5049","authenticated-orcid":false,"given":"Claudia","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reiter","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, University Hospital Mannheim Heidelberg University  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stengel","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8324791"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010020\u201001478\u20106"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2117206"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2021.12.006"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1776"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.016345"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.4983.4983"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.21918"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2007.05.020"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404194"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehpc.2015.10.001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.284121"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<192::AID-GCC2>3.0.CO;2-E"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2136948"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.4.1399"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.946517"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/crh\/5125740"},{"key":"e_1_2_12_19_1","volume-title":"WHO Classification of Tumours Editorial Board. 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