{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:15:29Z","timestamp":1779963329185,"version":"3.53.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>MEIS1::NCOA2 is a recurrent fusion gene primarily associated with genitourinary and gynecologic sarcomas, with no reported association with acute myeloid leukemia (AML) to date. We report the first case of AML in a 42\u2010year\u2010old woman with a novel MEIS1::NCOA2 fusion, identified by targeted RNA sequencing and validated by Sanger sequencing. This fusion arises from a t(2;8)(p14;q13.3) translocation that fuses MEIS1 exon 11 to NCOA2 exon 14; its MEIS1 breakpoint differs from the classic exons 6\/7 in sarcomas and retains nearly the full\u2010length functional domains of MEIS1 that are critical for leukemogenesis. This case expands the genomic and disease spectrum of MEIS1::NCOA2, identifies a unique AML\u2010associated breakpoint with potential leukemogenic roles, and warrants further functional and therapeutic investigation of this fusion gene.<\/jats:p>","DOI":"10.1002\/gcc.70121","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:17:43Z","timestamp":1778851063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel\n                    <i>MEIS1::NCOA2<\/i>\n                    Fusion Gene in Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"65","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated Zhangjiagang Hospital of Soochow University  Suzhou 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