{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:15:29Z","timestamp":1779963329213,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp;amp; Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute lymphoblastic leukemia (ALL) is a genetically heterogeneous malignancy characterized by a broad spectrum of chromosomal and gene abnormalities that define distinct genetic subtypes driving disease development. Although numerous driver fusion genes have been documented, a considerable proportion of ALL cases remain inadequately defined, classified, and consequently lack access to precisely targeted therapies. Herein, we report a case of high\u2010risk B\u2010ALL harboring four novel fusion gene transcripts\u2014\n                    <jats:italic>MAN1A1::GRIK2<\/jats:italic>\n                    ,\n                    <jats:italic>ZCCHC7::CASC11<\/jats:italic>\n                    ,\n                    <jats:italic>OSTM1\u2010AS1::ZBTB24<\/jats:italic>\n                    , and\n                    <jats:italic>IGL::BCL6<\/jats:italic>\n                    \u2014along with concurrent mutations in\n                    <jats:italic>CREBBP<\/jats:italic>\n                    ,\n                    <jats:italic>BCL2<\/jats:italic>\n                    , and\n                    <jats:italic>ARID1B<\/jats:italic>\n                    . These four novel fusion genes, particularly the\n                    <jats:italic>BCL6<\/jats:italic>\n                    rearrangement, may represent a genetic feature that warrants further investigation in B\u2010ALL. The patient received induction therapy with a modified COP regimen (cyclophosphamide, vindesine, dexamethasone) combined with the\n                    <jats:italic>BCL2<\/jats:italic>\n                    inhibitor venetoclax, achieving a rapid and sustained complete remission. This case suggests that integrating deep genomic analysis can help identify potentially actionable therapeutic targets and provides preliminary clinical evidence supporting the efficacy of modified COP plus venetoclax in high\u2010risk B\u2010ALL with similar molecular features, highlighting a promising precision medicine strategy.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70134","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:45:37Z","timestamp":1778582737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Fusion Gene Transcripts and Targetable Mutations in High\u2010Risk B\u2010\n                    <scp>ALL<\/scp>\n                    With Exceptional Response to Venetoclax\u2010Based Therapy"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8155-3794","authenticated-orcid":false,"given":"Jifang","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4080-3329","authenticated-orcid":false,"given":"Huanping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yungui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangli","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-4160","authenticated-orcid":false,"given":"Hongyan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Maligancies  Hangzhou China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou China"},{"name":"Zhejiang University Cancer Center Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)33018\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010024\u201000525\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2023.04.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1344839"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201011\u2010540658"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201003\u20101871"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202202216"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.710330"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010024\u201006114\u2010y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1131199"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00580"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199709068271"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1420782"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10351"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.60"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09727"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201059531\u20106"}],"container-title":["Genes, 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