{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:51:58Z","timestamp":1782391918950,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC) is a major global health burden with an increasing incidence among younger adults. High\u2010glycemic food intake and biological aging have been proposed as potential risk factors for CRC, but their causal relationships and underlying mechanisms remain unclear. We conducted a two\u2010sample Mendelian randomization (MR) study using large\u2010scale genome\u2010wide association study summary data to evaluate the genetic associations of 25 high\u2010glycemic food intake traits and five aging\u2010related indicators, including GrimAge acceleration, intrinsic epigenetic age acceleration, PhenoAge acceleration, Hannum age acceleration, and mitochondrial DNA copy number, with CRC risk. Two\u2010step MR was used to explore potential mediating role of aging indicators. MR analyses showed nominally significant positive associations of intake of sugar added to tea (OR\u2009=\u20091.307, 95% CI: 1.033\u20131.655,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026, FDR\u2009=\u20090.216) and doughnut intake (OR\u2009=\u20092.524, 95% CI: 1.317\u20134.835,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005, FDR\u2009=\u20090.131) with CRC risk, whereas yogurt intake was nominally associated with lower CRC risk (OR\u2009=\u20090.755, 95% CI: 0.596\u20130.958,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020, FDR\u2009=\u20090.216). These food\u2013CRC associations did not survive FDR correction and should therefore be interpreted as suggestive evidence. GrimAge acceleration showed a positive genetic association with CRC risk (OR\u2009=\u20091.102, 95% CI: 1.039\u20131.169,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Mediation analysis suggested that GrimAge acceleration may partly mediate the association between intake of sugar added to tea and CRC risk, with an estimated mediated proportion of 36.1%. These findings provide genetic evidence suggesting potential links among specific high\u2010glycemic food intake traits, epigenetic aging, and CRC risk; however, mediation finding did not pass strict significance testing and requires validation in larger and independent datasets.\n                  <\/jats:p>","DOI":"10.1002\/gcc.70149","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:31:32Z","timestamp":1781699492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Dietary Intake Traits and Aging Indicators With Colorectal Cancer: A Mendelian Randomization Study"],"prefix":"10.1002","volume":"65","author":[{"given":"Yuanlong","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Sanming First Hospital Affiliated to Fujian Medical University  Sanming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Sanming First Hospital Affiliated to Fujian Medical University  Sanming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Sanming First Hospital Affiliated to Fujian Medical University  Sanming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Sanming First Hospital Affiliated to Fujian Medical University  Sanming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Sanming First Hospital Affiliated to Fujian Medical University  Sanming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7672-4191","authenticated-orcid":false,"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Sanming First Hospital Affiliated to Fujian Medical University  Sanming 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